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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Michael Q. Blauwkamp, Timothy A. Yazawa, Masayuki Drukker, Micha Inlay, Matthew A. Weissman, Irving L. Abilez, Oscar J. Ali, Shah R. Nusse, Roeland Ardehali, Reza Gong, Yongquan |
| Description | Author Affiliation: Ardehali R ( Division of Cardiology, Department of Internal Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA. rardehali@mednet.ucla.edu); |
| Abstract | A goal of regenerative medicine is to identify cardiovascular progenitors from human ES cells (hESCs) that can functionally integrate into the human heart. Previous studies to evaluate the developmental potential of candidate hESC-derived progenitors have delivered these cells into murine and porcine cardiac tissue, with inconclusive evidence regarding the capacity of these human cells to physiologically engraft in xenotransplantation assays. Further, the potential of hESC-derived cardiovascular lineage cells to functionally couple to human myocardium remains untested and unknown. Here, we have prospectively identified a population of hESC-derived ROR2(+)/CD13(+)/KDR(+)/PDGFR (+) cells that give rise to cardiomyocytes, endothelial cells, and vascular smooth muscle cells in vitro at a clonal level. We observed rare clusters of ROR2(+) cells and diffuse expression of KDR and PDGFR in first-trimester human fetal hearts. We then developed an in vivo transplantation model by transplanting second-trimester human fetal heart tissues s.c. into the ear pinna of a SCID mouse. ROR2(+)/CD13(+)/KDR(+)/PDGFR (+) cells were delivered into these functioning fetal heart tissues: in contrast to traditional murine heart models for cell transplantation, we show structural and functional integration of hESC-derived cardiovascular progenitors into human heart. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 9 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Embryonic Stem Cells Cytology Fetus Heart Embryology Myocytes, Cardiac Transplantation Stem Cell Transplantation Animals Biological Markers Metabolism Cell Culture Techniques Cell Differentiation Cell Lineage Cell Separation Cells, Cultured Endothelium, Vascular Gene Expression Profiling Gene Expression Regulation, Developmental Mesoderm Mice Multipotent Stem Cells Myocardium Myocytes, Smooth Muscle Primitive Streak Receptor Tyrosine Kinase-like Orphan Receptors Genetics Receptor, Platelet-Derived Growth Factor Alpha Tissue Survival Vascular Endothelial Growth Factor Receptor-2 Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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