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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Carlezon, William A. Nader, Karim Pitman, Roger K. Li, Yan Milad, Mohammed R. Bolshakov, Vadim Y. Meloni, Edward G. |
| Description | Author Affiliation: Li Y ( Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.); |
| Abstract | Synaptic mechanisms underlying memory reconsolidation after retrieval are largely unknown. Here we report that synapses in projections to the lateral nucleus of the amygdala implicated in auditory fear conditioning, which are potentiated by learning, enter a labile state after memory reactivation, and must be restabilized through a postsynaptic mechanism implicating the mammalian target of rapamycin kinase-dependent signaling. Fear-conditioning-induced synaptic enhancements were primarily presynaptic in origin. Reconsolidation blockade with rapamycin, inhibiting mammalian target of rapamycin kinase activity, suppressed synaptic potentiation in slices from fear-conditioned rats. Surprisingly, this reduction of synaptic efficacy was mediated by post- but not presynaptic mechanisms. These findings suggest that different plasticity rules may apply to the processes underlying the acquisition of original fear memory and postreactivational stabilization of fear-conditioning-induced synaptic enhancements mediating fear memory reconsolidation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Amygdala Metabolism Physiology Synapses Synaptic Transmission Cytology Animals Anti-Bacterial Agents Pharmacology Microdissection Nerve Tissue Proteins Antagonists & Inhibitors Rats, Sprague-Dawley Sirolimus Drug Effects TOR Serine-Threonine Kinases Tissue Culture Techniques Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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