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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Endo, Yusuke Sugano, Sumio Ohkubo, Shuichi Tumes, Damon John Kanai, Akinori Onodera, Atsushi Iwamura, Chiaki Suzuki, Yutaka Hosokawa, Hiroyuki Kato, Miki Endoh, Kanji Tanaka, Tomoaki Nakayama, Toshinori |
| Description | Author Affiliation: Hosokawa H ( Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.); |
| Abstract | GATA binding protein 3 (Gata3) is a GATA family transcription factor that controls differentiation of naïve CD4 T cells into T helper 2 (Th2) cells. However, it is unknown how Gata3 simultaneously activates Th2-specific genes while repressing those of other Th lineages. Here we show that chromodomain helicase DNA-binding protein 4 (Chd4) forms a complex with Gata3 in Th2 cells that both activates Th2 cytokine transcription and represses the Th1 cytokine IFN-γ. We define a Gata3/Chd4/p300 transcriptional activation complex at the Th2 cytokine loci and a Gata3/Chd4-nucleosome remodeling histone deacetylase repression complex at the Tbx21 locus in Th2 cells. We also demonstrate a physiological role for Chd4 in Th2-dependent inflammation in an in vivo model of asthmatic inflammation. Thus, Gata3/Chd4 forms functionally distinct complexes, which mediate both positive and negative gene regulation to facilitate Th2 cell differentiation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Differentiation Immunology DNA Helicases Metabolism GATA3 Transcription Factor Multiprotein Complexes Th2 Cells Transcription, Genetic Animals Asthma Genetics Pathology Disease Models, Animal Genetic Loci Inflammation Interferon-gamma Mice Mice, Inbred BALB C Nucleosomes T-Box Domain Proteins Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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