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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ouyang, Yingshi Sarkar, Saumendra N. Bayer, Avraham Sadovsky, Yoel Coyne, Carolyn B. Donker, Rogier B. Stolz, Donna B. Mouillet, Jean-francois Morelli, Adrian E. Chu, Tianjiao Wang, Tianyi Delorme-axford, Elizabeth |
| Description | Author Affiliation: Delorme-Axford E ( Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.); |
| Abstract | Placental trophoblasts form the interface between the fetal and maternal environments and serve to limit the maternal-fetal spread of viruses. Here we show that cultured primary human placental trophoblasts are highly resistant to infection by a number of viruses and, importantly, confer this resistance to nonplacental recipient cells by exosome-mediated delivery of specific microRNAs (miRNAs). We show that miRNA members of the chromosome 19 miRNA cluster, which are almost exclusively expressed in the human placenta, are packaged within trophoblast-derived exosomes and attenuate viral replication in recipient cells by the induction of autophagy. Together, our findings identify an unprecedented paracrine and/or systemic function of placental trophoblasts that uses exosome-mediated transfer of a unique set of placental-specific effector miRNAs to directly communicate with placental or maternal target cells and regulate their immunity to viral infections. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 29 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Autophagy Genetics Chromosomes, Human, Pair 19 Disease Resistance MicroRNAs Placenta Cytology Trophoblasts Virology Virus Diseases Transmission Analysis Of Variance Cells, Cultured Enzyme-Linked Immunosorbent Assay Exosomes Metabolism Green Fluorescent Proteins Pregnancy Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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