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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nussenzweig, Michel C. Knops, Elena Mouquet, Hugo Ploss, Alexander Wilson, James M. Malbec, Marine Gravemann, Sophia Billerbeck, Eva Eisenreich, Thomas R. Seaman, Michael S. Rice, Charles M. Dorner, Marcus Kaiser, Rolf Büning, Hildegard Gitlin, Alexander D. Bjorkman, Pamela J. Horwitz, Joshua A. Schwartz, Olivier Tretiakova, Anna Klein, Florian Halper-stromberg, Ariel |
| Description | Author Affiliation: Horwitz JA ( Laboratory of Molecular Immunology, Laboratory of Virology and Infectious Diseases, and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065.); |
| Abstract | Effective control of HIV-1 infection in humans is achieved using combinations of antiretroviral therapy (ART) drugs. In humanized mice (hu-mice), control of viremia can be achieved using either ART or by immunotherapy using combinations of broadly neutralizing antibodies (bNAbs). Here we show that treatment of HIV-1-infected hu-mice with a combination of three highly potent bNAbs not only resulted in complete viremic control but also led to a reduction in cell-associated HIV-1 DNA. Moreover, lowering the initial viral load by coadministration of ART and immunotherapy enabled prolonged viremic control by a single bNAb after ART was withdrawn. Similarly, a single injection of adeno-associated virus directing expression of one bNAb produced durable viremic control after ART was terminated. We conclude that immunotherapy reduces plasma viral load and cell-associated HIV-1 DNA and that decreasing the initial viral load enables single bNAbs to control viremia in hu-mice. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 41 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Anti-Retroviral Agents Immunology Antibodies, Neutralizing HIV Infections Prevention & Control HIV-1 Drug Effects Immunotherapy Animals Pharmacology DNA Primers Genetics DNA, Viral Metabolism Dependovirus Drug Therapy, Combination Mice Mice, Transgenic Real-Time Polymerase Chain Reaction Sequence Analysis, DNA Viral Load Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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