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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lien, Nguyen Thi Nam Hien, Tran Tinh Dung, Tran Thi Ngoc Thuy, Cao Thu Kim, Dong Wook Minh, Pham Van Vinh, Ha Vinh, Phat Voong Thompson, Corinne Holt, Kathryn E. Vu Tra, My Phan Nhu, Nguyen Thi Khanh Dong, Nguyen Hoang, Nguyen Van Minh Thanh, Duy Pham Parry, Christopher M. Phuc, Hoang Le Tuyet, Pham Thi Ngoc Phu, Bui Duc Campbell, James I. Dougan, Gordon Parkhill, Julian Ai, Nguyen Thi Thuy Farrar, Jeremy J. Nga, Tran Thi Thu Thieu Nga, Tran Vu Vinh, Nguyen Thanh Thomson, Nicholas R. Baker, Stephen Tien, Nguyen Manh |
| Spatial Coverage | Vietnam |
| Description | Author Affiliation: Holt KE ( Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.); |
| Abstract | Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 43 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Dysentery, Bacillary Epidemiology Endemic Diseases Genetic Variation Shigella Sonnei Genetics Anti-Bacterial Agents Therapeutic Use Child, Preschool Chromosomes, Bacterial Ciprofloxacin Drug Therapy Microbiology Evolution, Molecular Fluoroquinolones Genome, Bacterial Genomics Geography Infant Molecular Sequence Data Mutation Rate Phylogeny Sequence Analysis, DNA Classification Physiology Vietnam Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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