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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lefort, Sandrine Gray, Annette C. Turrigiano, Gina G. |
| Description | Author Affiliation: Lefort S ( Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454.); |
| Abstract | Sensory microcircuits are refined by experience during windows of heightened plasticity termed 'critical periods' (CPs). In visual cortex the effects of visual deprivation change dramatically at the transition from the pre-CP to the CP, but the cellular plasticity mechanisms that underlie this change are poorly understood. Here we show that plasticity at unitary connections between GABAergic Fast Spiking (FS) cells and Star Pyramidal (SP) neurons within layer 4 flips sign at the transition between the pre-CP and the CP. During the pre-CP, coupling FS firing with SP depolarization induces long-term depression of inhibition at this synapse, whereas the same protocol induces long-term potentiation of inhibition at the opening of the CP. Despite being of opposite sign, both forms of plasticity share expression characteristics--a change in coefficient of variation with no change in paired-pulse ratio--and depend on GABAB receptor signaling. Finally, we show that the reciprocal SP â FS synapse also acquires the ability to undergo long-term potentiation at the pre-CP to CP transition. Thus, at the opening of the CP, there are coordinated changes in plasticity that allow specific patterns of activity within layer 4 to potentiate feedback inhibition by boosting the strength of FS â SP connections. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 47 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Critical Period (Psychology) GABAergic Neurons Physiology Long-Term Potentiation Neuronal Plasticity Synapses Visual Cortex Growth & Development Animals Neural Pathways Patch-Clamp Techniques Statistics, Nonparametric Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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