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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Plotkin, Scott R. Dietrich, Jorg Iafrate, A. John Sorensen, A. Greg Kalpathy-cramer, Jayashree Gerstner, Elizabeth R. Loeffler, Jay S. Chi, Andrew S. Pinho, Marco C. Lu-emerson, Christine Jain, Rakesh K. Ancukiewicz, Marek Polaskova, Pavlina Emblem, Kyrre E. Jennings, Dominique Snuderl, Matija Duda, Dan G. Ivy, S. Percy Wen, Patrick Y. Rosen, Bruce R. Batchelor, Tracy T. Eichler, April F. Hochberg, Fred H. |
| Description | Author Affiliation: Batchelor TT ( Department of Neurology, Department of Radiation Oncology, Department of Radiology, and Department of Pathology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA 02114.); |
| Abstract | Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms of action of antiangiogenic agents has hindered optimization and broader application of this new therapeutic modality. In particular, the impact of antiangiogenic therapy on tumor blood flow and oxygenation status (i.e., the role of vessel pruning versus normalization) remains controversial. This controversy has become critical as multiple phase III trials of anti-VEGF agents combined with cytotoxics failed to show overall survival benefit in newly diagnosed glioblastoma (nGBM) patients and several other cancers. Here, we shed light on mechanisms of nGBM response to cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, using MRI techniques and blood biomarkers in prospective phase II clinical trials of cediranib with chemoradiation vs. chemoradiation alone in nGBM patients. We demonstrate that improved perfusion occurs only in a subset of patients in cediranib-containing regimens, and is associated with improved overall survival in these nGBM patients. Moreover, an increase in perfusion is associated with improved tumor oxygenation status as well as with pharmacodynamic biomarkers, such as changes in plasma placenta growth factor and sVEGFR2. Finally, treatment resistance was associated with elevated plasma IL-8 and sVEGFR1 posttherapy. In conclusion, tumor perfusion changes after antiangiogenic therapy may distinguish responders vs. nonresponders early in the course of this expensive and potentially toxic form of therapy, and these results may provide new insight into the selection of glioblastoma patients most likely to benefit from anti-VEGF treatments. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 47 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Angiogenesis Inhibitors Pharmacology Brain Neoplasms Drug Therapy Metabolism Glioblastoma Oxygen Protein Kinase Inhibitors Tumor Markers, Biological Blood Pathology Radiotherapy DNA Modification Methylases DNA Repair Enzymes Dacarbazine Analogs & Derivatives Enzyme-Linked Immunosorbent Assay Magnetic Resonance Imaging Polymerase Chain Reaction Prospective Studies Quinazolines Receptor Protein-Tyrosine Kinases Statistics, Nonparametric Tumor Suppressor Proteins Clinical Trial, Phase II Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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