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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Decker, Markus Jülicher, Frank Zwicker, David Jaensch, Steffen Hyman, Anthony A. |
| Description | Author Affiliation: Zwicker D ( Max Planck Institute for the Physics of Complex Systems, Nö x{0308}thnitzer Strasse 38, 01187 Dresden, Germany); Decker M ( Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.); Jaensch S ( Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.); Hyman AA ( Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.); Jülicher F ( Max Planck Institute for the Physics of Complex Systems, Nö x{0308}thnitzer Strasse 38, 01187 Dresden, Germany); |
| Abstract | Centrosomes are highly dynamic, spherical organelles without a membrane. Their physical nature and their assembly are not understood. Using the concept of phase separation, we propose a theoretical description of centrosomes as liquid droplets. In our model, centrosome material occurs in a form soluble in the cytosol and a form that tends to undergo phase separation from the cytosol. We show that an autocatalytic chemical transition between these forms accounts for the temporal evolution observed in experiments. Interestingly, the nucleation of centrosomes can be controlled by an enzymatic activity of the centrioles, which are present at the core of all centrosomes. This nonequilibrium feature also allows for multiple stable centrosomes, a situation that is unstable in equilibrium phase separation. Our theory explains the growth dynamics of centrosomes for all cell sizes down to the eight-cell stage of the Caenorhabditis elegans embryo, and it also accounts for data acquired in experiments with aberrant numbers of centrosomes and altered cell volumes. Furthermore, the model can describe unequal centrosome sizes observed in cells with perturbed centrioles. We also propose an interpretation of the molecular details of the involved proteins in the case of C. elegans. Our example suggests a general picture of the organization of membraneless organelles. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 26 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Centrioles Metabolism Centrosome Chemistry Models, Chemical Catalysis Diffusion Kinetics Thermodynamics Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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