| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Zhang, Huimin Rittschof, Clare C. Ma, Jian Sinha, Saurabh Stubbs, Lisa Troy, Joseph M. Sloofman, Laura G. Cash-ahmed, Amy Weisner, Patricia A. Kent, Molly Robinson, Gene E. Sanogo, Yibayiri O. Bell, Alison M. Caetano-anollés, Derek Lu, Xiaochen Bukhari, Syed Abbas |
| Description |
Author Affiliation: Rittschof CC ( Institute for Genomic Biology, Departments of Entomology, Neuroscience Program, Department of Entomology, The Pennsylvania State University, University Park, PA 16802); Bukhari SA ( Institute for Genomic Biology, Illinois Informatics Institute.); Sloofman LG ( Institute for Genomic Biology, Center for Biophysics and Computational Biology, and.); Troy JM ( Institute for Genomic Biology, Illinois Informatics Institute.); Caetano-Anollés D ( Institute for Genomic Biology, Cell and Developmental Biology.); Cash-Ahmed A ( Institute for Genomic Biology, Departments of Entomology.); Kent M ( Institute for Genomic Biology, Neuroscience Program.); Lu X ( Institute for Genomic Biology, Cell and Developmental Biology.); Sanogo YO ( Institute for Genomic Biology, Genomics Core, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195.); Weisner PA ( Institute for Genomic Biology, Neuroscience Program.); Zhang H ( Institute for Genomic Biology, Cell and Developmental Biology.); Bell AM ( Institute for Genomic Biology, Neuroscience Program, Animal Biology, Program in Ecology, Evolution, and Conservation Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801); Ma J ( Institute for Genomic Biology, Bioengineering, and.); Sinha S ( Institute for Genomic Biology, Departments of Entomology, Computer Science.); Robinson GE ( Institute for Genomic Biology, Departments of Entomology, Neuroscience Program, Program in Ecology, Evolution, and Conservation Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801); Stubbs L ( Institute for Genomic Biology, Neuroscience Program, Cell and Developmental Biology, ccr22@illinois.edu generobi@illinois.edu ljstubbs@illinois.edu.); |
| Abstract |
Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly conserved genes and networks that may be modified by lineage-specific mutations. However, the existence of deeply conserved mechanisms for social behaviors has not yet been demonstrated. We used a comparative genomics approach to determine whether shared neuromolecular mechanisms could underlie behavioral response to territory intrusion across species spanning a broad phylogenetic range: house mouse (Mus musculus), stickleback fish (Gasterosteus aculeatus), and honey bee (Apis mellifera). Territory intrusion modulated similar brain functional processes in each species, including those associated with hormone-mediated signal transduction and neurodevelopment. Changes in chromosome organization and energy metabolism appear to be core, conserved processes involved in the response to territory intrusion. We also found that several homologous transcription factors that are typically associated with neural development were modulated across all three species, suggesting that shared neuronal effects may involve transcriptional cascades of evolutionarily conserved genes. Furthermore, immunohistochemical analyses of a subset of these transcription factors in mouse again implicated modulation of energy metabolism in the behavioral response. These results provide support for conserved genetic 'toolkits' that are used in independent evolutions of the response to social challenge in diverse taxa. |
| ISSN |
00278424 |
| e-ISSN |
10916490 |
| Journal |
Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number |
50 |
| Volume Number |
111 |
| Language |
English |
| Publisher |
National Academy of Sciences |
| Publisher Date |
2014-12-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Physiology Biological Evolution Brain Smegmamorpha Social Behavior Territoriality Animals Genetics DNA Primers Energy Metabolism Genomics Immunohistochemistry Mice Microscopy, Fluorescence Molecular Sequence Annotation Molecular Sequence Data Polymerase Chain Reaction Sequence Analysis, RNA Signal Transduction Species Specificity Transcription Factors Metabolism Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Multidisciplinary |
