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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sima, Richard J. Preat, Thomas Tanimoto, Hiromu Rubin, Gerald M. Plaçais, Pierre-yves Ichinose, Toshiharu Aso, Yoshinori Yamagata, Nobuhiro Friedrich, Anja B. |
| Description | Author Affiliation: Yamagata N ( Tohoku University Graduate School of Life Sciences, Sendai 980-8577, Japan); Ichinose T ( Tohoku University Graduate School of Life Sciences, Sendai 980-8577, Japan); Aso Y ( Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147); Plaçais PY ( Genes and Dynamics of Memory Systems, Brain Plasticity Unit, CNRS, Ecole Supérieure de Physique et de Chimie Industrielles-ParisTech, Paris Sciences et Lettres Research University, 75005 Paris, France.); Friedrich AB ( Max Planck Institut für Neurobiologie, Martinsried 82152, Germany); Sima RJ ( Max Planck Institut für Neurobiologie, Martinsried 82152, Germany); Preat T ( Genes and Dynamics of Memory Systems, Brain Plasticity Unit, CNRS, Ecole Supérieure de Physique et de Chimie Industrielles-ParisTech, Paris Sciences et Lettres Research University, 75005 Paris, France.); Rubin GM ( Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147); Tanimoto H ( Tohoku University Graduate School of Life Sciences, Sendai 980-8577, Japan); |
| Abstract | Drosophila melanogaster can acquire a stable appetitive olfactory memory when the presentation of a sugar reward and an odor are paired. However, the neuronal mechanisms by which a single training induces long-term memory are poorly understood. Here we show that two distinct subsets of dopamine neurons in the fly brain signal reward for short-term (STM) and long-term memories (LTM). One subset induces memory that decays within several hours, whereas the other induces memory that gradually develops after training. They convey reward signals to spatially segregated synaptic domains of the mushroom body (MB), a potential site for convergence. Furthermore, we identified a single type of dopamine neuron that conveys the reward signal to restricted subdomains of the mushroom body lobes and induces long-term memory. Constant appetitive memory retention after a single training session thus comprises two memory components triggered by distinct dopamine neurons. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Dopaminergic Neurons Physiology Drosophila Melanogaster Animals Animals, Genetically Modified Appetitive Behavior Carbohydrates Anatomy & Histology Genetics Memory, Long-Term Memory, Short-Term Mushroom Bodies Odors Taste Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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