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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Goronzy, Jörg J. Dekker, Cornelia L. Looney, Timothy J. Swan, Gary E. Boyd, Scott D. Le Saux, Sabine Dixit, Vaishali Lee, Ji-yeun Liu, Yi Wang, Chen Cavanagh, Mary M. Roskin, Krishna M. Qi, Qian |
| Description | Author Affiliation: Wang C ( Department of Pathology.); Liu Y ( Department of Pathology, Biomedical Informatics Training Program.); Cavanagh MM ( Division of Immunology and Rheumatology, Department of Medicine.); Le Saux S ( Division of Immunology and Rheumatology, Department of Medicine.); Qi Q ( Division of Immunology and Rheumatology, Department of Medicine.); Roskin KM ( Department of Pathology.); Looney TJ ( Department of Pathology.); Lee JY ( Department of Pathology.); Dixit V ( Department of Pathology.); Dekker CL ( Department of Pediatrics, and.); Swan GE ( Stanford Prevention Research Center, Stanford University, Stanford, CA 94305); Goronzy JJ ( Division of Immunology and Rheumatology, Department of Medicine, Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.); Boyd SD ( Department of Pathology, sboyd1@stanford.edu.); |
| Abstract | Adaptive immune responses in humans rely on somatic genetic rearrangements of Ig and T-cell receptor loci to generate diverse antigen receptors. It is unclear to what extent an individual's genetic background affects the characteristics of the antibody repertoire used in responding to vaccination or infection. We studied the B-cell repertoires and clonal expansions in response to attenuated varicella-zoster vaccination in four pairs of adult identical twins and found that the global antibody repertoires of twin pair members showed high similarity in antibody heavy chain V, D, and J gene segment use, and in the length and features of the complementarity-determining region 3, a major determinant of antigen binding. These twin similarities were most pronounced in the IgM-expressing B-cell pools, but were seen to a lesser extent in IgG-expressing B cells. In addition, the degree of antibody somatic mutation accumulated in the B-cell repertoire was highly correlated within twin pair members. Twin pair members had greater numbers of shared convergent antibody sequences, including mutated sequences, suggesting similarity among memory B-cell clonal lineages. Despite these similarities in the memory repertoire, the B-cell clones used in acute responses to ZOSTAVAX vaccination were largely unique to each individual. Taken together, these results suggest that the overall B-cell repertoire is significantly shaped by the underlying germ-line genome, but that stochastic or individual-specific effects dominate the selection of clones in response to an acute antigenic stimulus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antibodies, Viral Biosynthesis Genetics B-Lymphocytes Immunology Herpes Zoster Vaccine Herpesvirus 3, Human Twins, Monozygotic Cohort Studies Complementarity Determining Regions Immunoglobulin G Immunoglobulin Heavy Chains Immunoglobulin M Immunologic Memory Mutation Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Twin Study Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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