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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Stewart, Shannon Ghosh, Arpan C. Koh, Tong-wey Carlson, John R. |
| Description | Author Affiliation: Stewart S ( Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.); Koh TW ( Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.); Ghosh AC ( Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.); Carlson JR ( Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511 john.carlson@yale.edu.); |
| Abstract | We examine in Drosophila a group of â ¼35 ionotropic receptors (IRs), the IR20a clade, about which remarkably little is known. Of 28 genes analyzed, GAL4 drivers representing 11 showed expression in the larva. Eight drivers labeled neurons of the pharynx, a taste organ, and three labeled neurons of the body wall that may be chemosensory. Expression was not observed in neurons of one taste organ, the terminal organ, although these neurons express many drivers of the Gr (Gustatory receptor) family. For most drivers of the IR20a clade, we observed expression in a single pair of cells in the animal, with limited coexpression, and only a fraction of pharyngeal neurons are labeled. The organization of IR20a clade expression thus appears different from the organization of the Gr family or the Odor receptor (Or) family in the larva. A remarkable feature of the larval pharynx is that some of its organs are incorporated into the adult pharynx, and several drivers of this clade are expressed in the pharynx of both larvae and adults. Different IR drivers show different developmental dynamics across the larval stages, either increasing or decreasing. Among neurons expressing drivers in the pharynx, two projection patterns can be distinguished in the CNS. Neurons exhibiting these two kinds of projection patterns may activate different circuits, possibly signaling the presence of cues with different valence. Taken together, the simplest interpretation of our results is that the IR20a clade encodes a class of larval taste receptors. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drosophila Proteins Metabolism Drosophila Embryology Gene Expression Regulation, Developmental Receptors, Ionotropic Glutamate Taste Physiology Animals Central Nervous System Immunohistochemistry Larva Neurons Pharynx Sensory Receptor Cells Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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