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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Long Garbe, David S. Bashaw, Greg J. |
| Description | Author Affiliation: Yang L ( Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2/3, 421 Curie Boulevard, Philadelphia, PA 19104, USA.) |
| Abstract | Precise wiring of the nervous system depends on coordinating the action of conserved families of proteins that direct axons to their appropriate targets. Slit-roundabout repulsion and netrin-deleted in colorectal cancer (DCC) (frazzled) attraction must be tightly regulated to control midline axon guidance in vertebrates and invertebrates, but the mechanism mediating this regulation is poorly defined. Here, we show that the Fra receptor has two genetically separable functions in regulating midline guidance in Drosophila. First, Fra mediates canonical chemoattraction in response to netrin, and, second, it functions independently of netrin to activate commissureless transcription, allowing attraction to be coupled to the down-regulation of repulsion in precrossing commissural axons. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 5929 |
| Volume Number | 324 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2009-05-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Axons Physiology Drosophila Proteins Genetics Drosophila Melanogaster Gene Expression Regulation, Developmental Membrane Proteins Neurons Receptors, Cell Surface Metabolism Transcriptional Activation Animals Embryology Mutation Nerve Growth Factors Nerve Tissue Proteins Nervous System Growth & Development RNA, Messenger Receptors, Immunologic Signal Transduction Transcription, Genetic Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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