| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Christensen, Shawn A. Abdo, Zaid Doehlemann, Gunther Sims, James Mori, Naoki Ziemann, Sebastian Huffaker, Alisa Jander, Georg Schmitz, Robert J. Kolomiets, Michael V. Alborn, Hans T. Schmelz, Eric A. Kaplan, Fatma Ji, Lexiang Ni, Xinzhi Sartor, Ryan C. Byers, Sara |
| Description |
Author Affiliation: Christensen SA ( Chemistry Research Unit, Center for Medical, Agricultural, and Veterinary Entomology, Department of Agriculture-Agricultural Research Service (USDA-ARS), Gainesville, FL 32608); Huffaker A ( Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, CA 92093-0380); Kaplan F ( Kaplan Schiller Research, Gainesville, FL 32604); Sims J ( Department of Environmental Systems Science, ETH Zurich, 8092 Zurich, Switzerland); Ziemann S ( Cologne Biocenter/Botanical Institute, University of Cologne, 50674 Cologne, Germany); Doehlemann G ( Cologne Biocenter/Botanical Institute, University of Cologne, 50674 Cologne, Germany); Ji L ( Institute of Bioinformatics, University of Georgia, Athens, GA 30602); Schmitz RJ ( Department of Genetics, University of Georgia, Athens, GA 30602); Kolomiets MV ( Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX 77843); Alborn HT ( Chemistry Research Unit, Center for Medical, Agricultural, and Veterinary Entomology, Department of Agriculture-Agricultural Research Service (USDA-ARS), Gainesville, FL 32608); Mori N ( Graduate School of Agriculture, Kyoto University, Kitashirakawa, Sakyo, 606-8502 Kyoto, Japan); Jander G ( Boyce Thompson Institute for Plant Research, Ithaca, NY 14853); Ni X ( Crop Genetics and Breeding Research Unit, USDA-ARS, Tifton, GA 31793); Sartor RC ( Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, CA 92093-0380); Byers S ( South Atlantic Area Office, USDA-ARS, Athens, GA 30605.); Abdo Z ( South Atlantic Area Office, USDA-ARS, Athens, GA 30605.); Schmelz EA ( Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, CA 92093-0380); |
| Abstract |
Plant damage promotes the interaction of lipoxygenases (LOXs) with fatty acids yielding 9-hydroperoxides, 13-hydroperoxides, and complex arrays of oxylipins. The action of 13-LOX on linolenic acid enables production of 12-oxo-phytodienoic acid (12-OPDA) and its downstream products, termed 'jasmonates.' As signals, jasmonates have related yet distinct roles in the regulation of plant resistance against insect and pathogen attack. A similar pathway involving 9-LOX activity on linolenic and linoleic acid leads to the 12-OPDA positional isomer, 10-oxo-11-phytodienoic acid (10-OPDA) and 10-oxo-11-phytoenoic acid (10-OPEA), respectively; however, physiological roles for 9-LOX cyclopentenones have remained unclear. In developing maize (Zea mays) leaves, southern leaf blight (Cochliobolus heterostrophus) infection results in dying necrotic tissue and the localized accumulation of 10-OPEA, 10-OPDA, and a series of related 14- and 12-carbon metabolites, collectively termed 'death acids.' 10-OPEA accumulation becomes wound inducible within fungal-infected tissues and at physiologically relevant concentrations acts as a phytoalexin by suppressing the growth of fungi and herbivores including Aspergillus flavus, Fusarium verticillioides, and Helicoverpa zea. Unlike previously established maize phytoalexins, 10-OPEA and 10-OPDA display significant phytotoxicity. Both 12-OPDA and 10-OPEA promote the transcription of defense genes encoding glutathione S transferases, cytochrome P450s, and pathogenesis-related proteins. In contrast, 10-OPEA only weakly promotes the accumulation of multiple protease inhibitor transcripts. Consistent with a role in dying tissue, 10-OPEA application promotes cysteine protease activation and cell death, which is inhibited by overexpression of the cysteine protease inhibitor maize cystatin-9. Unlike jasmonates, functions for 10-OPEA and associated death acids are consistent with specialized roles in local defense reactions. |
| ISSN |
00278424 |
| e-ISSN |
10916490 |
| Journal |
Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number |
36 |
| Volume Number |
112 |
| Language |
English |
| Publisher |
National Academy of Sciences |
| Publisher Date |
2015-09-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Cyclopentanes Metabolism Lipoxygenase Plant Proteins Sesquiterpenes Zea Mays Ascomycota Physiology Chemistry Pharmacology Cystatins Genetics Gene Expression Profiling Gene Expression Regulation, Plant Drug Effects Host-Pathogen Interactions Immunoblotting Magnetic Resonance Spectroscopy Molecular Structure Oligonucleotide Array Sequence Analysis Oxylipins Plant Diseases Microbiology Reverse Transcriptase Polymerase Chain Reaction Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Multidisciplinary |
