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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhu, Xiaoyu Li, Shundai Gu, Ying Bashline, Logan |
| Description | Author Affiliation: Bashline L ( Center for Lignocellulose Structure and Formation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802.); Li S ( Center for Lignocellulose Structure and Formation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802.); Zhu X ( Center for Lignocellulose Structure and Formation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802.); Gu Y ( Center for Lignocellulose Structure and Formation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802 yug13@psu.edu.); |
| Abstract | Cellulose biosynthesis is performed exclusively by plasma membrane-localized cellulose synthases (CESAs). Therefore, the trafficking of CESAs to and from the plasma membrane is an important mechanism for regulating cellulose biosynthesis. CESAs were recently identified as cargo proteins of the classic adaptor protein 2 (AP2) complex of the clathrin-mediated endocytosis (CME) pathway. The AP2 complex of the CME pathway is conserved in yeast, animals, and plants, and has been well-characterized in many systems. In contrast, the recently discovered TPLATE complex (TPC), which is proposed to function as a CME adaptor complex, is only conserved in plants and a few other eukaryotes. In this study, we discovered that the TWD40-2 protein, a putative member of the TPC, is also important for the endocytosis of CESAs. Genetic analysis between TWD40-2 and AP2M of the AP2 complex revealed that the roles of TWD40-2 in CME are both distinct from and cooperative with the AP2 complex. Loss of efficient CME in twd40-2-3 resulted in the unregulated overaccumulation of CESAs at the plasma membrane. In seedlings of twd40-2-3 and other CME-deficient mutants, a direct correlation was revealed between endocytic deficiency and cellulose content deficiency, highlighting the importance of controlled CESA endocytosis in regulating cellulose biosynthesis. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 41 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Arabidopsis Proteins Metabolism Arabidopsis Cellulose Biosynthesis Clathrin Endocytosis Physiology Glucosyltransferases Cytology Genetics Mutation Protein Transport Seedling Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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