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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rütgen, Markus Riecanský, Igor Lamm, Claus Seidel, Eva-maria Petrovic, Predrag Silani, Giorgia Hummer, Allan Windischberger, Christian |
| Description | Author Affiliation: Rütgen M ( Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna 1010, Austria); Seidel EM ( Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna 1010, Austria); Silani G ( Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste 34136, Italy); Riecanský I ( Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna 1010, Austria); Hummer A ( Medical Research (MR) Center of Excellence, Medical University of Vienna, Vienna 1090, Austria); Windischberger C ( Medical Research (MR) Center of Excellence, Medical University of Vienna, Vienna 1090, Austria); Petrovic P ( Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden.); Lamm C ( Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna 1010, Austria); |
| Abstract | Empathy for pain activates brain areas partially overlapping with those underpinning the first-hand experience of pain. It remains unclear, however, whether such shared activations imply that pain empathy engages similar neural functions as first-hand pain experiences. To overcome the limitations of previous neuroimaging research, we pursued a conceptually novel approach: we used the phenomenon of placebo analgesia to experimentally reduce the first-hand experience of pain, and assessed whether this results in a concomitant reduction of empathy for pain. We first carried out a functional MRI experiment (n = 102) that yielded results in the expected direction: participants experiencing placebo analgesia also reported decreased empathy for pain, and this was associated with reduced engagement of anterior insular and midcingulate cortex: that is, areas previously associated with shared activations in pain and empathy for pain. In a second step, we used a psychopharmacological manipulation (n = 50) to determine whether these effects can be blocked via an opioid antagonist. The administration of the opioid antagonist naltrexone blocked placebo analgesia and also resulted in a corresponding 'normalization' of empathy for pain. Taken together, these findings suggest that pain empathy may be associated with neural responses and neurotransmitter activity engaged during first-hand pain, and thus might indeed be grounded in our own pain experiences. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 41 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Analgesia Brain Physiopathology Empathy Magnetic Resonance Imaging Naltrexone Administration & Dosage Narcotic Antagonists Neuroimaging Pain Placebo Effect Radiography Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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