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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ji, Yaoting Stachnik, Agnes Calvano, Cosima D. Colaianni, Graziana Davies, Terry F. Tamma, Roberto Yuen, Tony Colucci, Silvia Cuscito, Concetta New, Maria I. Sun, Li Zhu, Ling-ling Zaidi, Mone Liu, Peng Grano, Maria Dhawan, Samarth Zambonin, Carlo G. Zallone, Alberta Di Benedetto, Adriana Bailey, Jack Lu, Ping |
| Description | Author Affiliation: Sun L ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Tamma R ( Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy); Yuen T ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Colaianni G ( Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy); Ji Y ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Cuscito C ( Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy); Bailey J ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Dhawan S ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Lu P ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Calvano CD ( Department of Chemistry, University of Bari Aldo Moro, Bari 70124, Italy); Zhu LL ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Zambonin CG ( Department of Chemistry, University of Bari Aldo Moro, Bari 70124, Italy); Di Benedetto A ( Department of Clinical and Experimental Medicine, University of Foggia, Foggia 71122, Italy.); Stachnik A ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Liu P ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Grano M ( Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy); Colucci S ( Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy); Davies TF ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); New MI ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Zallone A ( Department of Basic Medical Science, Neurosciences and Sensory Organs, University of Bari, 70124 Bari, Italy); Zaidi M ( The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029); |
| Abstract | Prior studies show that oxytocin (Oxt) and vasopressin (Avp) have opposing actions on the skeleton exerted through high-affinity G protein-coupled receptors. We explored whether Avp and Oxtr can share their receptors in the regulation of bone formation by osteoblasts. We show that the Avp receptor 1 (Avpr1 ) and the Oxt receptor (Oxtr) have opposing effects on bone mass: Oxtr(-/-) mice have osteopenia, and Avpr1 (-/-) mice display a high bone mass phenotype. More notably, this high bone mass phenotype is reversed by the deletion of Oxtr in Oxtr(-/-):Avpr1 (-/-) double-mutant mice. However, although Oxtr is not indispensable for Avp action in inhibiting osteoblastogenesis and gene expression, Avp-stimulated gene expression is inhibited when the Oxtr is deleted in Avpr1 (-/-) cells. In contrast, Oxt does not interact with Avprs in vivo in a model of lactation-induced bone loss in which Oxt levels are high. Immunofluorescence microscopy of isolated nucleoplasts and Western blotting and MALDI-TOF of nuclear extracts show that Avp triggers Avpr1 localization to the nucleus. Finally, a specific Avpr2 inhibitor, tolvaptan, does not affect bone formation or bone mass, suggesting that Avpr2, which primarily functions in the kidney, does not have a significant role in bone remodeling. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 113 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2016-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Arginine Vasopressin Physiology Bone Density Bone Remodeling Osteogenesis Oxytocin Receptors, Vasopressin Metabolism Amino Acid Sequence Animals Pharmacology Blotting, Western Drug Effects Genetics Bone Diseases, Metabolic Gene Deletion Mice Mice, Mutant Strains Molecular Sequence Data Osteoblasts Receptors, Oxytocin Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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