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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lim, Xinhong Yu, Ka Lou Tan, Si Hui Nusse, Roeland Lim, Sophia Beng Hui |
| Description | Author Affiliation: Lim X ( Institute of Medical Biology, Agency for Science, Technology, and Research, Singapore 138648); Tan SH ( Institute of Medical Biology, Agency for Science, Technology, and Research, Singapore 138648); Yu KL ( Institute of Medical Biology, Agency for Science, Technology, and Research, Singapore 138648); Lim SB ( Institute of Medical Biology, Agency for Science, Technology, and Research, Singapore 138648); Nusse R ( Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5329); |
| Abstract | How stem cells maintain their identity and potency as tissues change during growth is not well understood. In mammalian hair, it is unclear how hair follicle stem cells can enter an extended period of quiescence during the resting phase but retain stem cell potential and be subsequently activated for growth. Here, we use lineage tracing and gene expression mapping to show that the Wnt target gene Axin2 is constantly expressed throughout the hair cycle quiescent phase in outer bulge stem cells that produce their own Wnt signals. Ablating Wnt signaling in the bulge cells causes them to lose their stem cell potency to contribute to hair growth and undergo premature differentiation instead. Bulge cells express secreted Wnt inhibitors, including Dickkopf (Dkk) and secreted frizzled-related protein 1 (Sfrp1). However, the Dickkopf 3 (Dkk3) protein becomes localized to the Wnt-inactive inner bulge that contains differentiated cells. We find that Axin2 expression remains confined to the outer bulge, whereas Dkk3 continues to be localized to the inner bulge during the hair cycle growth phase. Our data suggest that autocrine Wnt signaling in the outer bulge maintains stem cell potency throughout hair cycle quiescence and growth, whereas paracrine Wnt inhibition of inner bulge cells reinforces differentiation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 11 |
| Volume Number | 113 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2016-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Axin Protein Metabolism Hair Follicle Cytology Stem Cells Wnt Signaling Pathway Physiology Beta Catenin Animals Autocrine Communication Genetics Gene Expression Regulation Intercellular Signaling Peptides And Proteins Membrane Proteins Mice, Mutant Strains Mice, Transgenic Wnt Proteins Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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