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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gislason, Gunnar H. Madsen, Jan Kyst Grove, Erik L. Hansen, Peter Riis Lindhardsen, Jesper Ahlehoff, Ole Charlot, Mette Torp-pedersen, Christian Olesen, Jonas B. Køber, Lars Selmer, Christian |
| Spatial Coverage | Denmark |
| Description | Author Affiliation: Charlot M ( Department of Cardiology, Copenhagen University Hospital Gentofte, Post 635, Niels Andersens Vej 65, 2900 Hellerup, Denmark. mc@heart.dk); |
| Abstract | Objective To examine the effect of proton pump inhibitors on adverse cardiovascular events in aspirin treated patients with first time myocardial infarction. Design Retrospective nationwide propensity score matched study based on administrative data. Setting All hospitals in Denmark. Participants All aspirin treated patients surviving 30 days after a first myocardial infarction from 1997 to 2006, with follow-up for one year. Patients treated with clopidogrel were excluded. Main outcome measures The risk of the combined end point of cardiovascular death, myocardial infarction, or stroke associated with use of proton pump inhibitors was analysed using Kaplan-Meier analysis, Cox proportional hazard models, and propensity score matched Cox proportional hazard models. Results 3366 of 19 925 (16.9%) aspirin treated patients experienced recurrent myocardial infarction, stroke, or cardiovascular death. The hazard ratio for the combined end point in patients receiving proton pump inhibitors based on the time dependent Cox proportional hazard model was 1.46 (1.33 to 1.61; P<0.001) and for the propensity score matched model based on 8318 patients it was 1.61 (1.45 to 1.79; P<0.001). A sensitivity analysis showed no increase in risk related to use of $H_{2}$ receptor blockers (1.04, 0.79 to 1.38; P=0.78). Conclusion In aspirin treated patients with first time myocardial infarction, treatment with proton pump inhibitors was associated with an increased risk of adverse cardiovascular events. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Volume Number | 342 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 2011-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Aspirin Adverse Effects Myocardial Infarction Drug Therapy Platelet Aggregation Inhibitors Proton Pump Inhibitors Cardiovascular Diseases Chemically Induced Mortality Drug Interactions Kaplan-Meier Estimate Prognosis Propensity Score Recurrence Retrospective Studies Risk Factors Stroke Multicenter Study Research Support, Non-U.S. Gov't Medicine |
| Content Type | Text |
| Resource Type | Article |
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