NDLI: Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study

Please wait, while we are loading the content...

Year: 2017 Volume: 356

Year: 2017 Volume: 353

Year: 2017 Volume: 346

Year: 2016 Volume: 534

Year: 2016 Volume: 532

Year: 2016 Volume: 356

Year: 2016 Volume: 355

Year: 2016 Volume: 354

Year: 2016 Volume: 353

Year: 2016 Volume: 352

Year: 2016 Volume: 351

Year: 2015 Volume: 351

Year: 2015 Volume: 350

Year: 2015 Volume: 349

Year: 2014 Volume: 349

Year: 2014 Volume: 348

Year: 2013 Volume: 347

Year: 2013 Volume: 346

Year: 2012 Volume: 346

Year: 2012 Volume: 345

Year: 2012 Volume: 344

Year: 2011 Volume: 344

Year: 2011 Volume: 343

Year: 2011 Volume: 342

More than half of infants in developing countries are breast fed for less than six months, report says.

Costs and cost effectiveness of different strategies for chlamydia screening and partner notification: an economic and mathematical modelling study

How the case against the MMR vaccine was fixed.

Wakefield's article linking MMR vaccine and autism was fraudulent.

Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial

Research into scorpion stings.

Substance abuse atlas highlights gaps in provision of care.

Experts urge vaccination to try to control cholera outbreak in Haiti.

Frequency and reasons for outcome reporting bias in clinical trials: interviews with trialists

Hypothyroidism in a patient with non-alcoholic fatty liver disease

Beware the fortune tellers peddling genetic tests.

Health ministers may call for appraisal of unlicensed cancer drug for eye treatment.

Republicans act to repeal health reform as they take control of House of Representatives.

H1N1 vaccine is released in UK to meet demand for protection against flu

NHS quality accounts are failing to tell the whole story.

Australian doctors report high rates of job satisfaction.

Bremen doctors sign up to reduce drug use in ADHD patients.

Identifying and managing deprivation of liberty in adults in England and Wales.

Germany suspends decision to stop some hospitals treating very low birth weight babies.

Hospitals should offer bingo and art sessions, says BMA.

Secrets of the MMR scare . How the vaccine crisis was meant to make money.

Nail changes in a patient with leukaemia.

Employee ownership in the NHS. Transition to employee ownership.

Gout. Aspects of management.

Gout. Management in primary care.

Infective endocarditis. Time to monitor incidence after NICE guidance.

Rushing to clamp umbilical cord. More evidence is needed to inform practice.

Rushing to clamp umbilical cord. Until safety and benefit are proved, better not to rush.

Referrals to secondary care. NICE 'referral advice' recommendations database.

Orphan drugs. EU regulations.

Cardioverter defibrillators. Should not be implanted in isolation after infarction.

Cardiovascular safety of NSAIDs.

Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis

Ensuring safe and effective drugs: who can do what it takes?

Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study

Regulating research.

BMA warns against letting patients have access to their electronic records.

Haiti is faced with sudden rise in birth rate.

International response risks undermining Haiti's health system, warns relief agency.

Access to clinical trial data.

WHO unveils plan to stop artemisinin resistance 'dead in its tracks'.

Association of change in daily step count over five years with insulin sensitivity and adiposity: population based cohort study

Regulation and governance of clinical research in the UK.

Organ donors and transplantations decrease in Spain, the leading country in both.

Waiting times for tests show sharp rises since targets were relaxed.

Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis

Pharmacists state ambition to expand their role in community health.

HFEA canvasses on whether to increase compensation to egg and sperm donors.

Ethics and effectiveness: rationing healthcare by thresholds of minimum effectiveness.

Community services for people who have had a stroke are 'patchy,' says watchdog.

New cancer strategy for England focuses on earlier diagnosis.

Cross-border healthcare in the European Union: clarifying patients’ rights

Decline in US abortion rate has stalled, report says.

Illinois assembly votes to abolish death penalty, but governor hesitates.

Transplantations fall in Israel as new law complicates procedures.

Brazil puts emergency medical plan into action.

Australia faces huge rebuild after devastating floods.

Cameron defends moving NHS 'from closed markets to open systems'.

New oral anticoagulants for thromboprophylaxis in patients having hip or knee arthroplasty.

Regulator drops cases against pharmacies offering homoeopathic malaria prophylaxis.

Secrets of the MMR scare. The Lancet's two days to bury bad news.

Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study

Assuring research integrity in the wake of Wakefield.

Travel websites should highlight malaria risks.

French drug reps. Say no to seeing sales reps.

The life imprisonment of Dr Binayak Sen.

The BMJ is on the iPad.

Too many referral forms?. Hail, universal referral form.

Denialism in public health. Beware SLEAZE tactics.

Point of credulity. Professor McLachlan's fraud.

Middle ear forceps. Likened to pike in German.

A French king's head. Was it Henri IV's head?

Phantom vibration syndrome. Sixty eight per cent of us hallucinate.

Cycling and health. Pernicious use of surrogate markers.

Thrombolysis in elderly people. Observational data insufficient to change treatment.

Overweening on weaning.

Doctor who received £1.2m from patient’s estate is struck off

Why do pharmacists sell homoeopathic remedies?

Early detection of complications after laparoscopic surgery: summary of a safety report from the National Patient Safety Agency.

Diagnosis and management of hereditary haemochromatosis.

Is research safe in their hands?

Planned alcohol pricing will have 'negligible impact' on health problems, say critics.

Finding the techniques to nudge the population to better health.

Joint hypermobility syndrome. (Journal: BMJ (British Medical Journal) Volume: 342)

Use of non-steroidal anti-inflammatory drugs and risk of Parkinson’s disease: nested case-control study

Doctors are reluctant to use telemedicine and misunderstand what patients want, says NHS Confederation report.

Head of inquiry into WHO’s handling of the H1N1 pandemic says he will present a “critical” report

Republicans win vote in House of Representatives to repeal health reform bill.

Healthcare in Turkey: from laggard to leader.

Monitoring adherence to drug treatment by using change in cholesterol concentration: secondary analysis of trial data

Islet transplantation in type 1 diabetes

Dr Lansley's monster.

New hygiene law aims to reduce infections in German hospitals.

Food and drink industry rejects claims of irresponsibility over obesity and alcoholism.

Going local: devolving national pay for performance programmes.

Palliative care in people with chronic obstructive pulmonary disease.

Living and dying with severe chronic obstructive pulmonary disease: multi-perspective longitudinal qualitative study

Guidance on assisted suicide is confusing and risky, Warnock tells commission.

Cochrane review questions evidence for statins for primary prevention in low risk groups.

European parliament agrees rules on cross border healthcare.

Primary prevention of cardiovascular disease.

Vaccination programme to protect children against pneumonia and diarrhoea needs more funds.

Hospital closures are inevitable under health reforms, conference hears.

Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis

Vitamin D and bone health in children.

Competing interests: When do your politics become a competing interest?

Portrayal of caesarean section in Brazilian women’s magazines: 20 year review

Carbamazepine in pregnancy: Levetiracetam and lamotrigine are better options.

Embryology: New life for the HFEA?

Reference intakes of vitamin D: Need to be implemented in UK.

Treatment abroad: A long journey to healing.

Febrile neutropenia: national guidelines are urgently needed.

Assisted dying debate: Try another approach, BMJ.

Assisted dying debate: Put everything out in the open.

MMR scare: UCL's response.

Assisted dying debate: Let's get the words right too.

Assisted dying debate: What of virtue and integrity?

Piltdown—hoax or fraud?

Insulin manufacture: Marketing insulins.

Industry sponsored bias: NICE may be biased too.

Guns don’t kill crowds, people with semi-automatics do

Philadelphia doctor who ran 'baby charnel house' is charged with murder.

Hong Kong's murky skyline is linked with excess deaths.

WHO calls for action to restrict marketing of unhealthy foods and drinks to children.

Rich countries dominate cancer league table.

Effect of pay for performance on the management and outcomes of hypertension in the United Kingdom: interrupted time series study

Judging nudging: can nudging improve population health?

One nudge forward, two steps back.

Management of generalised anxiety disorder in adults: summary of NICE guidance.

Personal view. Should the spectacle of surgery be sold to the highest bidder?

Health and social care bill.

Governments call on WHO to improve cholera control.

Families at risk of genetically high cholesterol are not being spotted, says royal college.

Greed isn't good.

An odd eruption.

Adverse outcomes from IVF.

Does poor health justify NHS reform?

High smoking rates in 1940s, 1950s and 1960s in US explain comparatively lower life expectancy of older Americans

Russians are unable to buy aspirin, paracetamol, and other basic drugs because of official bungle.

Last US manufacturer of drug used in executions stops production.

Experts express doubts that food and drink industries have the motives to improve health.

Outcomes of chest compression only CPR versus conventional CPR conducted by lay people in patients with out of hospital cardiopulmonary arrest witnessed by bystanders: nationwide population based observational study

Chest compression or conventional CPR after out of hospital cardiac arrest?

Legal action delays ban on tobacco displays in Scotland.

Influenza B is now predominant strain, as flu cases continue to fall.

US health department recovers \$4bn through antifraud action

Radiotherapy in UK is feared and underused.

Spain's tougher line on smoking in public places spreads to other countries.

Essential care after an inpatient fall: summary of a safety report from the National Patient Safety Agency.

Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study

Anticoagulation in people with atrial fibrillation.

'Dangerous' locum surgeon is struck off medical register.

Impact of a statewide intensive care unit quality improvement initiative on hospital mortality and length of stay: retrospective comparative analysis

FDA panel advice may require trials to prove safety of ECT.

Hong Kong schoolchildren get training to detect dementia in elderly relatives.

The assessment and management of rectal prolapse, rectal intussusception, rectocoele, and enterocoele in adults.

Definitely not acceptable: drug company sues journal over review.

MEPs criticise WHO over H1N1 pandemic advice

Germany pushes for more organ donation.

Bad medicine: cardiology.

One billion people are affected by global shortage of healthcare workers.

NHS drug budget. Flawed assumption in analysis.

Out of hospital cardiac arrest. Time for a national register.

Infective endocarditis. NICE calls for a register.

Access to clinical trial data. Data monitoring committees and selective outcome reporting.

Reduced access to database. A publicly available database accelerates academic production.

Flu questions and answers. Flu's impact on intensive care.

Research approval. The regulation killing health research in the UK.

Florida judge says entire health reform act is unconstitutional.

Gates and Cameron pledge new money to eradicate polio.

MPs support NHS reform as health bill passes first parliament debate.

An asthmatic child with a troublesome cough.

Well enough to work?

We should push for evidence based sentencing in criminal justice.

'Make the care of your patient your first concern'.

Heart heal thyself: a new direction for cardiac research.

Donor countries have responsibility to root out corruption in aid flows.

Telehealthcare for long term conditions.

Effect of training traditional birth attendants on neonatal mortality (Lufwanyama Neonatal Survival Project): randomised controlled study

Poor inpatient care for older people.

Is quality of care improving in the UK?

Enteroviruses and type 1 diabetes

Effectiveness of AS03 adjuvanted pandemic H1N1 vaccine: case-control evaluation based on sentinel surveillance system in Canada, autumn 2009

Large scale organisational intervention to improve patient safety in four UK hospitals: mixed method evaluation

Multiple component patient safety intervention in English hospitals: controlled evaluation of second phase

Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies

Audiovisual feedback and quality of CPR.

Does home oxygen benefit people with chronic heart failure?

Research to decrease areas of clinical uncertainty.

Effect of real-time feedback during cardiopulmonary resuscitation outside hospital: prospective, cluster-randomised trial

Pfizer closes Kent plant as it trims research spending by \$1bn a year

Number of UK women who will get breast cancer has risen to one in eight.

Switzerland is to fund complementary therapies for six years while effectiveness is evaluated.

US Republicans try to restrict health insurance cover for abortion.

Conventional versus automated measurement of blood pressure in primary care patients with systolic hypertension: randomised parallel design controlled trial

Measurement of blood pressure in primary care.

Strategy for intention to treat analysis in randomised trials with missing outcome data.

Improving cardiovascular health at population level: 39 community cluster randomised trial of Cardiovascular Health Awareness Program (CHAP)

US Senate doesn't repeal health reform, but states defy the act.

Safety agency calls for old syringe drivers to be phased out, after deaths.

New male doctors earned 17% more than female doctors in US in 2008

New patent rules boost profits while safe drugs elude the world's poor, says Oxfam.

Death row prisoners sue FDA for allowing unapproved execution drug to be imported.

List of 'wanted' US healthcare thieves is posted on the web.

International agencies call for end to female genital mutilation.

Researcher didn’t get ethical approval for 68 studies, investigators say

'Disruptive' doctors are often found to be perfectionists, agency reports.

Postmarketing studies of drug safety.

Pandemic influenza vaccines.

Paediatric ENT surgery. Grommets and cholesteatoma.

Publicity of NHS breast cancer screening programme is unfair.

Understating under-reporting

Laparoscopy complications. Apply safety rule of thumb.

Aviation and patient safety. Send in the marines?

Aviation and patient safety. We cannot go too far in the pursuit of patient safety.

MMR scare. Robust procedures for research conduct are needed.

MMR scare. In the wake of Wakefield.

MMR scare. Response from the UK Research Integrity Office.

MMR scare. The BMJ's measly editorial policies.

MMR scare. Are the GMC, news media, and BMJ the right tribunals?

GMC's revalidation plans don't tackle problem of poorly performing doctors, MPs say.

Neck lump in a young woman.

Private finance initiatives during NHS austerity.

Outcomes of kidney transplantation are better in Spain than the US, a study finds.

Payment by results may undermine services for drug users, warn specialists.

WHO backs further probes into possible link between H1N1 vaccine and narcolepsy in children

Improving patient safety through education.

Qualitative methods: an alternative view.

Withholding versus withdrawal of life support: is there an ethical difference?

Old drugs, new tricks.

Lactation wars.

Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study

The protective effects of helmets in skiers and snowboarders.

Reduction of childhood mortality through millennium development goal 4

Interpretation of random effects meta-analyses

Treatment of breast infection.

Ireland has record fall in number of organ donations.

Four in 100 deaths worldwide are caused by alcohol, says WHO

Competition in the NHS in England.

Spanish government appeals against new law on generics in Galicia that is set to save €93m a year

Ruling prevents women taking second abortion pill at home.

Baby P doctor is allowed to remove herself from medical register.

When to wean. Infection more important than anaemia or allergy.

Joint hypermobility syndrome. Urinary incontinence as presenting feature.

Joint hypermobility syndrome. Implications for obstetric care.

Gun control. Australian and US gun deaths compared.

Nations with endemic malaria are urged to scrap taxes and tariffs on drugs and tests.

Peer support for patients with type 2 diabetes: cluster randomised controlled trial

In for the long haul.

When to wean. Analysis article on breast feeding was misleading.

Living and dying with COPD. End of life trajectories across conditions.

Living and dying with COPD. What happens in neurological disease.

COPD exacerbations. Anxious not to be breathless.

Joint hypermobility syndrome. Psychiatric manifestations.

C reactive protein and the risk of cardiovascular disease.

Trends in mortality from 1965 to 2008 across the English north-south divide: comparative observational study

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

The north-south health divide

Doctors criticise proposed changes to the undergraduate medical curriculum in India.

Kidney donor is awarded £6.74m after “negligent and reckless” operation

'Harrowing accounts' show how NHS fails to meet basic standards of care of elderly people.

A pneumococcal vaccine is launched in Africa to cut child deaths.

Global initiative launches to speed up the discovery of new drugs.

Advocacy and concerted action are needed to tackle rising rates of malnutrition.

A boy with a painful arm.

Explaining the unexplainable.

Global HPV vaccination.

Medicine and the Media. How useful are lifetime risks of disease?

Statins for primary prevention of cardiovascular disease. (Journal: BMJ (British Medical Journal) Volume: 342)

Type 1 diabetes in children

Glucagon-like peptide-1 analogues for type 2 diabetes

The other Twitter revolution: how social media are helping to monitor the NHS reforms.

Circumcision in boys and girls: why the double standard?

Court of Protection is asked to impose sterilisation on woman with learning disabilities.

NICE consults on improving consent rates for organ donation.

Private health sector could face reduced business as NHS tightens its belt.

Agency aims to inform girls about contraception to promote development.

Pharmacological prevention of migraine.

Americans are living longer, but obesity and diabetes are rising.

New European guidelines on atrial fibrillation.

Generalised anxiety disorder. Recommendation on sertraline.

Assisted dying debate. Time to be neutral?

High blood pressure in young people and premature death.

A smarter way to practise.

Chronic disease to top agenda. Legislation trumps individual interventions.

Chronic disease to top agenda. Beware tobacco companies' spurious financial arguments.

Chronic disease to top agenda. Cardiorespiratory fitness is an important risk factor.

Anticoagulation in AF. Anticoagulation uptake remains poor in high risk patients.

Anticoagulation in AF. Stroke and dementia are also chronic diseases.

European Union clamps down on fake drugs.

Health services for prisoners.

Association of blood pressure in late adolescence with subsequent mortality: cohort study of Swedish male conscripts

Research regulation. Limits of anonymisation in NHS data systems.

Patent rules must not hinder access to cheap drugs in poor countries, experts say.

Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies

Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis

Widening access to medical education for under-represented socioeconomic groups: population based cross sectional analysis of UK data, 2002-6

NICE publishes guidance to improve diagnosis of food allergy in children.

Shift to green world economy would help reduce death and disease, report finds.

New initiative to make systematic review protocols more transparent.

Libyan hospitals are overstretched treating thousands of victims of violent crackdown.

Pigmentation and confusion.

Accessible medical research.

Emotional distress in infertile women and failure of assisted reproductive technologies: meta-analysis of prospective psychosocial studies

Role of brain imaging in early parkinsonism.

Diagnosis, assessment, and management of harmful drinking and alcohol dependence: summary of NICE guidance.

Should 'legal highs' be regulated as medicinal products?

Diagnosis and assessment of food allergy in children and young people: summary of NICE guidance.

Minimum alcohol pricing in England.

Budget cutting US Republicans try to end funds for family planning and health reform.

How the media helped ban mephedrone.

Provision of acute stroke care and associated factors in a multiethnic population: prospective study with the South London Stroke Register

NHS launches legal action against makers of Gaviscon.

Recurrence after unprovoked venous thromboembolism.

Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis

Safer insertion of suprapubic catheters: summary of a safety report from the National Patient Safety Agency.

Food allergy. (Journal: BMJ (British Medical Journal) Volume: 342)

NHS reforms create threat to patient confidentiality.

Vaccine manufacturers cannot be sued over design defects, US Supreme Court rules.

The risks of radiation exposure related to diagnostic imaging and how to minimise them.

US Medicaid programme grows to cover 50 million low income people

Lost in translation: be aware of patients' lives.

All the world's knowledge.

Employers in China flout laws which ban the testing of employees for hepatitis B.

Governments need to invest more to deal with health risks of teenagers, says Unicef.

Humanitarian corridor set up in Egypt as Libyan casualties escalate.

Australia moves to combat the misuse of prescription opioids.

Improved survival at low lung function in cystic fibrosis: cohort study from 1990 to 2007

English law on assisted suicide needs updating, commission hears.

Leaders of US medicine speak out on health effects of climate change.

Australia makes a start on primary healthcare reform, at last.

Blood pressure measurement. Oscillometric devices are good in routine practice.

Free speech and duty. Sleeping dogs should have been left to lie.

Free speech and duty. Juniors needed support over MMC/MTAS.

Traits of 'disruptive doctors'. The sin is not perfectionism but poor leadership.

Old drugs, new tricks. Intravenous lipid emulsions in anaesthesia.

Use of skin lightening creams. Some clinical pointers to use.

Aviation in patient safety. UK surgery already applies aviation safety practice.

View from English pilot site of safer patients initiative.

View from Scottish pilot site of Safer Patients Initiative.

Is quality of care improving? What about value for money?

Is quality of care improving? Hospital safety and complexity.

Is quality of care improving? Improvement efforts need to be targeted at junior doctors.

Use of skin lightening creams. Survey in a UK general practice.

Use of skin lightening creams. Dangers from mercury.

Tobacco firms move to stop FDA banning menthol cigarettes.

Beer is no longer food for Russians.

Czech doctors win wage increases after three year campaign.

How doctors are re-engineering the immune system to fight HIV infection

One year cancer survival rates in England remain poor despite national strategies, report finds.

Association of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective cohort study

Is breast cancer associated with tobacco smoking?

What's happening to waiting times?

Cannabis and the increased incidence and persistence of psychosis.

Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study

Weight loss and hyponatraemia.

New York bans smoking almost everywhere.

Bad medicine: gynaecological examinations.

After baby P: can GPs follow child protection guidance?

Online healthcare advertising needs regulation.

A new mental health strategy for England.

The rule of ignorance: a polemic on medicine, English health service policy, and history.

Should physicians routinely be involved in the care of elderly surgical patients? Yes.

Should physicians be routinely involved in the care of elderly surgical patients? No.

Atypical antipsychotic drugs.

Can we have a culture of patient safety without one of staff safety?

Investigating hyponatraemia.

Italian court edict over discharge rules causes controversy.

Telemedicine may cut emergency admissions for COPD.

US citizens report slightly less sexual activity than in 2002

Cystic fibrosis and survival in patients with advanced lung disease.

Improving child health services in the UK: insights from Europe and their implications for the NHS reforms.

Ethnicity and academic performance in the UK.

Ethnicity and academic performance in UK trained doctors and medical students: systematic review and meta-analysis

Quality of chronic disease care for older people in care homes and the community in a primary care pay for performance system: retrospective study

Research output on primary care in Australia, Canada, Germany, the Netherlands, the United Kingdom, and the United States: bibliometric analysis

Using bibliometrics to define the quality of primary care research.

Use of weekly, low dose, high frequency ultrasound for hard to heal venous leg ulcers: the VenUS III randomised controlled trial

All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study

Excess mortality in osteoarthritis.

Doctor who injected her sister with unlicensed drug is struck off register.

Avoid 50% dextrose

Hypoglycaemia unawareness.

Use of GLP-1 analogues needs great caution

Are GLP-1 analogues affordable?

Care of elderly people. Is there freedom of speech in the medical profession?

Local authority budget cuts and health inequalities

Spanish move away from Mediterranean diet.

German doctors are told to have an open attitude to placebos.

Talking therapies: can the centre hold?

UN recommends reparations fund to help those who were raped in Congo.

Prisoners' mental health could suffer if GPs fail to commission services, warn psychiatrists.

Atypical diabetic retinopathy.

A young woman with rigors and abdominal pain.

It's unethical for general practitioners to be commissioners.

The hunt for the mystery genes.

The management of abdominal aortic aneurysms.

Charity pays drug addicts to use long term contraception.

Europe provides €172m for research into innovative medicines

Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review

Efficacy of drug treatments for generalised anxiety disorder: systematic review and meta-analysis

Drug treatment for generalised anxiety disorder.

Government delays in banning tobacco displays in England lead to frustration.

Illinois governor finally signs bill outlawing death penalty.

Correlation in restricted ranges of data.

Indian court says it may sanction euthanasia in the future.

Withholding medical care from detainees is widespread, says UN.

Adult atopic eczema.

Growth hormone in children with idiopathic short stature.

Adequacy of reporting monitoring regimens of risk factors for cardiovascular disease in clinical guidelines: systematic review

Early life radiation exposure. Withholding imaging in pregnancy may be hazardous.

Utility of lifetime risks. In defence of lifetime risk.

Mephedrone. Banned but still available on the internet.

Pre-eclampsia is a risk marker

Dementia as chronic disease. Rigorous health infrastructure is needed.

Best practice for statisticians in industry sponsored trials.

Prevention of pain from propofol injection.

Prevention of pain on injection of propofol: systematic review and meta-analysis

Malaria. (Journal: BMJ (British Medical Journal) Volume: 342)

French healthcare: the high cost of excellence.

Public health reforms won't mitigate the cuts.

Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials

How to minimise risk of acquiring tuberculosis when working in a high prevalence setting: a guide for healthcare workers.

Nine million Americans have lost health insurance in recession.

Inquiry into doping case by Freiburg sports medicine institute reveals possible plagiarism.

Poor countries should use flexibility in global trade agreement to improve access to antiretrovirals, says report.

Strengthening the reporting of genetic risk prediction studies: the GRIPS statement.

A painful right leg.

Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies

What have we learnt from the rosiglitazone saga?

Commentary: the Dutch approach to unwarranted medical practice variation.

Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients

Herbal medicines will need to be registered with drug regulator to be sold in UK.

Pituitary infarction: a potentially fatal cause of postoperative hyponatraemia and ocular palsy.

Pituitary apoplexy. (Journal: BMJ (British Medical Journal) Volume: 342)

Managing adult patients who need home parenteral nutrition.

Human rights group accuses US psychiatrists of unethical treatment of prisoners.

Dutch doctors face fine for prescribing pregnancy hormone as dieting aid.

Virtual hospital for HIV patients halves consultation times.

Databriefing. How satisfied are we with the NHS?

New proposals for reorganisation of healthcare staff in England.

Medicine and the Media. Panic about nuclear apocalypse overshadows Japan's real plight.

Reducing unwarranted variations in healthcare in the English NHS.

Death toll climbs and healthcare needs escalate in Japan.

Report shows low rate of cancer surgery in middle aged people.

Libya's health system struggles after exodus of foreign medical staff.

Salzburg statement on shared decision making.

How services for long term conditions could be reborn.

Poor nutrition is increasing rates of overweight in developing countries.

Biomedical approach cannot deal with India's public health problems, says health activist.

Cardiac surgeons call for more doctors to use outcome data to improve care.

Draft bill sets out how courts should weed out unreliable expert witnesses.

Increase in alcohol sales in Scotland is driven by low prices and rising affluence.

Why have working hour restrictions apparently not improved patient safety?

Impact of reduction in working hours for doctors in training on postgraduate medical education and patients’ outcomes: systematic review

How the secretary of state for health proposes to abolish the NHS in England.

The production of generic drugs in India.

We need a simple test for prosopagnosia.

Drug Tales and Other Stories. Prescription charges: a tax on the English.

Systematic failures and alternatives to audit.

Test all patients in high prevalence areas for HIV, says NICE.

Bigger is better for primary care.

Inpatient management of diabetic foot problems: summary of NICE guidance.

Assessment and management of psychosis with coexisting substance misuse: summary of NICE guidance.

Results can be summarised in a simple figure

Gynaecological examinations. Good not bad medicine.

Old drugs, new tricks . Use of intravenous lipids in clinical toxicology.

Southeast London—the unspoken problem

GPs and child protection. Medical records should be shared by all.

GPs and child protection. Online conferencing might be the answer.

Government says no to lowering drink driving limit in UK.

US authorities face legal challenges over anaesthetics used in executions.

A 42 year old man with bilateral exophthalmos and weight loss

A man with hypophosphataemia.

King's Fund report on improving the quality of care in general practice.

Alcohol marketing to children.

Life threatening myelotoxicity secondary to azathioprine in a patient with atopic eczema and normal thiopurine methyltransferase activity.

More needs to be done to tackle the 'double cruelty' of HIV and TB in Africa, says government.

Protecting public health after major radiation emergencies.

Quality of care in frail older people: the fragile balance between receiving and giving.

China pushes ahead with ban on indoor smoking.

US institute points up inconsistencies between guidelines on same condition.

The influence of study characteristics on reporting of subgroup analyses in randomised controlled trials: systematic review

A glimpse of the future of healthcare at the seaside.

Response to drug resistant tuberculosis is insufficient and too slow.

Campaigners call for university to close down children's chiropractic clinic in Melbourne.

Wilmshurst faces new libel claim over comments on freedom of speech.

Clinically integrated systems: the future of NHS reform in England?

Investigation and management of unintentional weight loss in older adults.

Transitions to palliative care in acute hospitals in England: qualitative study

Widening access to medical school. Access schemes are not enough.

Widening access to medical school. Could proficiency in English be a factor?

Widening access to medical school. Ethnicity and academic performance.

Appeal to doctor-patient relationship is unprofessional and unethical

Unethical health reforms . The reforms are already working.

Unethical health reforms. This ethical argument seems irrelevant to the real world.

New drugs for hyponatraemia. Cost effectiveness of tolvaptan.

QOF exemptions and care homes. Exemptions should be encouraged in frail elderly people.

Exposure from fluoroscopy in theatre.

Medical radiation exposure. Assigning a cumulative 'risk score'.

Medical radiation exposure. Making the best use of clinical radiology.

Turkish healthcare reforms. Article was a gift to minister of health just before general election.

Turkish healthcare reforms. 'Transforming' our health by privatisation.

Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial

Type of anaesthesia during cancer surgery and cancer recurrence.

College investigates whether Wakefield was guilty of scientific fraud.

US government is to promote 'wellness' among its employees.

Chronic diarrhoea in an elderly woman.

Statin treatment for primary prevention of vascular disease: whom to treat? Cost-effectiveness analysis

Randomised prostate cancer screening trial: 20 year follow-up

Rebound hypoxaemia after administration of oxygen in an acute exacerbation of chronic obstructive pulmonary disease.

Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trial

Diagnosis and management of transient ischaemic attack and ischaemic stroke in the acute phase.

Can the government's proposals for NHS reform be made to work?

UK Supreme Court abolishes immunity for expert witnesses.

Tuberculosis: a clear and present danger.

Surgeon who pleads guilty to two charges of manslaughter and 21 of causing harm gets four years in prison

WHO warns noise pollution is a growing hazard to health in Europe.

Pathologist in G20 demonstration death is suspended for “irresponsible” conduct in earlier case

Group therapy for adolescents with repeated self harm: randomised controlled trial with economic evaluation

Frequent exacerbations in chronic obstructive pulmonary disease.

Understanding provision of chemotherapy to patients with end stage cancer: qualitative interview study

Commentary: Fixing the policy may not sort out the politics.

Which idea is likely to make the biggest impact on healthcare by 2020?

UN calls for 'bold' action to reshape AIDS response.

Dutch smokers are 'alarmingly' ignorant of harms of passive smoking, study finds.

New South African HIV strategy targets condom use and miners.

Migration of doctors and the 'fitness to practise' process.

Place of medical qualification and outcomes of UK General Medical Council “fitness to practise” process: cohort study

Climate change, ill health, and conflict.

Improving the management of COPD.

Reporting of eligibility criteria of randomised trials: cohort study comparing trial protocols with subsequent articles

SACN iron recommendations. Pregnancy is a special case.

New mental health strategy. Uncosted, unrealistic strategy.

Evidence based policy making. How can it be achieved?

Osteoarthritis excess mortality. Painful limping and early death.

GH in idiopathic short stature. Is growth hormone treatment ethical or cost effective?

GH in idiopathic short stature. Is treating a poorly defined illness ethical?

National alcohol plans. New Zealand's alcohol plan is less than 'half hearted'.

Atypical antipsychotic drugs. Two points of clinical interest.

Number of organ donors rises by 15% in Spain after doctors are given good practice guide

Power to the people.

Welcome to the century of the patient.

Effect of statin treatment on short term mortality after pneumonia episode: cohort study

Management of acute bronchiolitis.

Home mechanical ventilation.

Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis

Statins and pneumonia.

Use of bombs in populated areas is having a devastating effect on civilians, say reports.

Diagnostic dilemma in an elderly woman.

Economic evaluation alongside randomised controlled trials: design, conduct, analysis, and reporting.

Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort

Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study

Economic evaluation using decision analytical modelling: design, conduct, analysis, and reporting.

Multidisciplinary palliative care in unborn and newborn babies.

Putting evidence into practice.

Defence questions validity of evidence against cardiologist facing charges of sex abuse.

Through the wasteland: chronic depression.

Journal withdraws article after complaints from drug manufacturers.

Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial

Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies

Closed loop control for type 1 diabetes

Effect of oxandrolone and timing of pubertal induction on final height in Turner’s syndrome: randomised, double blind, placebo controlled trial

Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis

Comparison of rates of adverse events in adolescent and adult women undergoing medical abortion: population register based study

Outreach education for integration of HIV/AIDS care, antiretroviral treatment, and tuberculosis care in primary care clinics in South Africa: PALSA PLUS pragmatic cluster randomised trial

Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: nested case-control study based on UK General Practice Research Database

Risk of non-fatal venous thromboembolism in women using oral contraceptives containing drospirenone compared with women using oral contraceptives containing levonorgestrel: case-control study using United States claims data

Angiotensin receptor blockers and risk of myocardial infarction: meta-analyses and trial sequential analyses of 147 020 patients from randomised trials

Hysterectomy, endometrial ablation, and levonorgestrel releasing intrauterine system (Mirena) for treatment of heavy menstrual bleeding: cost effectiveness analysis

Levothyroxine dose and risk of fractures in older adults: nested case-control study

Impact of the NICE guideline recommending cessation of antibiotic prophylaxis for prevention of infective endocarditis: before and after study

Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study

Thyroid autoantibodies, preterm birth, and miscarriage.

New recommendations on autism spectrum disorder.

Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence

Effect of β blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study

Inadequate reporting of research ethics review and informed consent in cluster randomised trials: review of random sample of published trials

Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched study

Road safety plan aims to save five million lives in next 10 years

Antismoking campaigners lambast packs of 14 cigarettes

Ukraine must loosen drugs policy to allow patients access to oral morphine, says report.

UK stroke performance still improving after 12 years of scrutiny

A comparison of clinical officers with medical doctors on outcomes of caesarean section in the developing world: meta-analysis of controlled studies

Europeans are left to their own devices.

The regulation of medical devices.

Commentary: Use of registries to investigate the past and develop the future.

Commentary: Evaluating and regulating device therapy.

Out of joint: the story of the ASR.

Commentary: International collaboration needed on device clinical standards.

Medical device recalls and transparency in the UK.

Commentary: Metal on metal hips.

Commentary: The risk of over-regulation

Diagnosis and management of schistosomiasis.

Lateral wedge insoles for medial knee osteoarthritis: 12 month randomised controlled trial

Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial

Surgery with disc prosthesis versus rehabilitation in patients with low back pain and degenerative disc: two year follow-up of randomised study

Human papillomavirus testing in primary cervical screening and the cut-off level for hybrid capture 2 tests: systematic review

Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants’ data from seven trials

Dietary calcium intake and risk of fracture and osteoporosis: prospective longitudinal cohort study

Intraoperative fluid management guided by oesophageal Doppler monitoring

Longitudinal analysis of sleep in relation to BMI and body fat in children: the FLAME study

Effect of weekly vitamin D supplements on mortality, morbidity, and growth of low birthweight term infants in India up to age 6 months: randomised controlled trial

Association between waiting times and short term mortality and hospital admission after departure from emergency department: population based cohort study from Ontario, Canada

Longer term effects of very low energy diet on obstructive sleep apnoea in cohort derived from randomised controlled trial: prospective observational follow-up study

Effect of evidence based risk information on “informed choice” in colorectal cancer screening: randomised controlled trial

Cryotherapy versus salicylic acid for the treatment of plantar warts (verrucae): a randomised controlled trial

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review

Evidence against the proposition that “UK cancer survival statistics are misleading”: simulation study with National Cancer Registry data

Global health diplomacy: how foreign policy can influence health.

Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study

Perinatal outcomes after maternal 2009/H1N1 infection: national cohort study

Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials

Association between maternal sleep practices and risk of late stillbirth: a case-control study

Effectiveness of a multifaceted podiatry intervention to prevent falls in community dwelling older people with disabling foot pain: randomised controlled trial

Effectiveness of anonymised information sharing and use in health service, police, and local government partnership for preventing violence related injury: experimental study and time series analysis

Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial

High risk prescribing in primary care patients particularly vulnerable to adverse drug events: cross sectional population database analysis in Scottish general practice

Priorities for women with lymphoedema after treatment for breast cancer: population based cohort study

Predicting risk of osteoporotic and hip fracture in the United Kingdom: prospective independent and external validation of QFractureScores

Performance of stroke risk scores in older people with atrial fibrillation not taking warfarin: comparative cohort study from BAFTA trial

Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension: systematic review

Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework

Cause specific mortality, social position, and obesity among women who had never smoked: 28 year cohort study

Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study

The NHS is right to fund homoeopathy.

Year: 2011 Volume: 341

Year: 2010 Volume: 342

Year: 2010 Volume: 341

Year: 2010 Volume: 340

Year: 2009 Volume: 339

Year: 2009 Volume: 338

Year: 2008 Volume: 337

Year: 2008 Volume: 336

Year: 2007 Volume: 335

Year: 2007 Volume: 334

Year: 2006 Volume: 333

Year: 2006 Volume: 332

Year: 2005 Volume: 331

Year: 2005 Volume: 330

Year: 2004 Volume: 329

Year: 2004 Volume: 328

Year: 2003 Volume: 327

Year: 2003 Volume: 326

Year: 2002 Volume: 325

Year: 2002 Volume: 324

Year: 2001 Volume: 323

Year: 2001 Volume: 322

Year: 2000 Volume: 321

Year: 2000 Volume: 320

Year: 1999 Volume: 319

Year: 1999 Volume: 318

Year: 1998 Volume: 317

Year: 1998 Volume: 316

Year: 1997 Volume: 315

Year: 1997 Volume: 314

Year: 1996 Volume: 313

Year: 1996 Volume: 312

Year: 1995 Volume: 311

Year: 1995 Volume: 310

Year: 1994 Volume: 309

Year: 1994 Volume: 308

Year: 1993 Volume: 307

Year: 1993 Volume: 306

Year: 1992 Volume: 305

Year: 1992 Volume: 304

Year: 1991 Volume: 303

Year: 1991 Volume: 302

Year: 1990 Volume: 301

Year: 1990 Volume: 300

Year: 1989 Volume: 299

Year: 1989 Volume: 298

Year: 1988 Volume: 297

Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tang, Rebecca Y. K. Zhang, Xiuqing Lam, Helena Tang, Mary H. Y. Nicolaides, Kypros H. Chiu, Rossa W. K. Minekawa, Ryoko To, William W. K. Leung, Wing C. Wang, Jun Au-yeung, Sidney K. C. Lo, Y. M. Dennis Lau, Tze K. Zheng, Yama W. L. Leung, Tak Y. Oudejans, Cees B. M. Akolekar, Ranjit Lun, Fiona M. F. Kung, Yu Y. Go, Attie T. J. I. Van Vugt, John M. G. Chan, K. C. Allen Sun, Hao Lau, Elizabeth T.
Description	Author Affiliation: Chiu RW ( Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.);
Abstract	Objectives To validate the clinical efficacy and practical feasibility of massively parallel maternal plasma DNA sequencing to screen for fetal trisomy 21 among high risk pregnancies clinically indicated for amniocentesis or chorionic villus sampling. Design Diagnostic accuracy validated against full karyotyping, using prospectively collected or archived maternal plasma samples. Setting Prenatal diagnostic units in Hong Kong, United Kingdom, and the Netherlands. Participants 753 pregnant women at high risk for fetal trisomy 21 who underwent definitive diagnosis by full karyotyping, of whom 86 had a fetus with trisomy 21. Intervention Multiplexed massively parallel sequencing of DNA molecules in maternal plasma according to two protocols with different levels of sample throughput: 2-plex and 8-plex sequencing. Main outcome measures Proportion of DNA molecules that originated from chromosome 21. A trisomy 21 fetus was diagnosed when the z score for the proportion of chromosome 21 DNA molecules was >3. Diagnostic sensitivity, specificity, positive predictive value, and negative predictive value were calculated for trisomy 21 detection. Results Results were available from 753 pregnancies with the 8-plex sequencing protocol and from 314 pregnancies with the 2-plex protocol. The performance of the 2-plex protocol was superior to that of the 8-plex protocol. With the 2-plex protocol, trisomy 21 fetuses were detected at 100% sensitivity and 97.9% specificity, which resulted in a positive predictive value of 96.6% and negative predictive value of 100%. The 8-plex protocol detected 79.1% of the trisomy 21 fetuses and 98.9% specificity, giving a positive predictive value of 91.9% and negative predictive value of 96.9%. Conclusion Multiplexed maternal plasma DNA sequencing analysis could be used to rule out fetal trisomy 21 among high risk pregnancies. If referrals for amniocentesis or chorionic villus sampling were based on the sequencing test results, about 98% of the invasive diagnostic procedures could be avoided.
ISSN	09598138
e-ISSN	17561833
Journal	BMJ (British Medical Journal)
Volume Number	342
Language	English
Publisher	British Medical Journal Publishing Group
Publisher Date	2011-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Down Syndrome Diagnosis Prenatal Diagnosis Sequence Analysis, DNA Case-Control Studies DNA Blood Karyotyping Maternal Age Pregnancy ROC Curve Sensitivity And Specificity Sex Determination Processes Multicenter Study Validation Studies Medicine
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in