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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dennison Himmelfarb, Cheryl R. Shanholtz, Carl Desai, Sanjay V. Pronovost, Peter J. Needham, Dale M. Mendez-tellez, Pedro A. Dinglas, Victor D. Sevransky, Jonathan E. Colantuoni, Elizabeth Brower, Roy G. |
| Spatial Coverage | Baltimore |
| Description | Author Affiliation: Needham DM ( Outcomes After Critical Illness and Surgery Group, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Dale.Needham@jhmi.edu); |
| Abstract | Objective To evaluate the association of volume limited and pressure limited (lung protective) mechanical ventilation with two year survival in patients with acute lung injury. Design Prospective cohort study. Setting 13 intensive care units at four hospitals in Baltimore, Maryland, USA. Participants 485 consecutive mechanically ventilated patients with acute lung injury. Main outcome measure Two year survival after onset of acute lung injury. Results 485 patients contributed data for 6240 eligible ventilator settings, as measured twice daily (median of eight eligible ventilator settings per patient; 41% of which adhered to lung protective ventilation). Of these patients, 311 (64%) died within two years. After adjusting for the total duration of ventilation and other relevant covariates, each additional ventilator setting adherent to lung protective ventilation was associated with a 3% decrease in the risk of mortality over two years (hazard ratio 0.97, 95% confidence interval 0.95 to 0.99, P=0.002). Compared with no adherence, the estimated absolute risk reduction in two year mortality for a prototypical patient with 50% adherence to lung protective ventilation was 4.0% (0.8% to 7.2%, P=0.012) and with 100% adherence was 7.8% (1.6% to 14.0%, P=0.011). Conclusions Lung protective mechanical ventilation was associated with a substantial long term survival benefit for patients with acute lung injury. Greater use of lung protective ventilation in routine clinical practice could reduce long term mortality in patients with acute lung injury. Trial registration Clinicaltrials.gov {"type":"clinical-trial","attrs":{"text":"NCT00300248","term_id":"NCT00300248"}}NCT00300248. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Volume Number | 344 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Acute Lung Injury Mortality Respiration, Artificial Therapy Baltimore Epidemiology Prospective Studies Risk Factors Survival Rate Tidal Volume Time Factors Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Medicine |
| Content Type | Text |
| Resource Type | Article |
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