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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Khatry, Subarna K. Pillion, Joseph Leclerq, Steven C. Schmitz, Jane Sommer, Alfred West, Keith P. Wu, Lee Katz, Joanne Karna, Sureswor L. |
| Spatial Coverage | Nepal |
| Description | Author Affiliation: Schmitz J ( Institute for Global Health and Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.); |
| Abstract | Objective To determine whether vitamin A supplementation administered in the preschool years can lower the risk of hearing loss in adolescence and adulthood. Design Follow-up study of adolescents and young adults who, as preschool aged children in 1989, were enrolled into a cluster randomised, double blinded, placebo controlled trial of vitamin A supplementation. Setting South central, rural Nepal. Participants 2378 adolescents and young adults aged 14 to 23, representing 51% of those who finished the original trial and 71% of those living in the study area in 2006. Interventions Every four months for 16 months preschool children were visited at home, given an oral 200 000 IU dose of vitamin A (half dose at age 1-11 months, quarter dose at <1 month) or placebo and the parents were queried about any childhood illnesses in the previous week, including purulent discharge from the ears. Main outcome measures Prevalence of mild or worse hearing loss (≥30 dB) in the most affected ear and tympanometric measures of middle ear function (peak height, ear canal volume, and gradient). Results During the original trial, the prevalence of middle ear infection during the preschool years did not differ between the supplement groups. By adolescence and early adulthood, a non-significant 17% reduction in hearing loss occurred among those who had periodically received vitamin A compared with placebo as preschool aged children (odds ratio 0.83, 95% confidence interval 0.62 to 1.12). Among participants with any ear discharge in early childhood, vitamin A supplementation was associated with a reduced risk of hearing loss, by 42% (0.58, 0.37 to 0.92) compared with controls, after adjusting the confidence interval for the design effect of the original trial. Abnormal tympanometric peak height of the middle ear system was less likely among participants supplemented with vitamin A in childhood. Conclusion In undernourished settings, periodic, high dose vitamin A supplementation may reduce the risk of hearing loss associated with purulent ear infections in early childhood. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Volume Number | 344 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 2012-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Dietary Supplements Hearing Loss Prevention & Control Otitis Media, Suppurative Complications Vitamin A Therapeutic Use Vitamins Adolescent Child, Preschool Double-Blind Method Drug Administration Schedule Follow-Up Studies Etiology Infant Logistic Models Odds Ratio Rural Health Randomized Controlled Trial Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Medicine |
| Content Type | Text |
| Resource Type | Article |
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