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Year: 2015 Volume: 11 Issue: 3

Year: 2015 Volume: 11 Issue: 2

Year: 2015 Volume: 11 Issue: 1

Year: 2014 Volume: 10

Inflammatory bowel disease in Turkish children.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cakir, Murat Unal, Fatih Dinler, Gonul Baran, Masallah Yuksekkaya, Hasan Ali Tumgor, Gokhan Kasirga, Erhun Kalayci, Ayhan Gazi Aydogdu, Sema
Spatial Coverage	Turkey
Description	Country affiliation: Turkey Author Affiliation: Cakir M ( , Trabzon, Turkey. muratcak@hotmail.com.); Unal F ( , Trabzon, Turkey.); Dinler G ( Dortcelik Children Hospital, Bursa, Turkey.); Baran M ( , Trabzon, Turkey.); Yuksekkaya HA ( 19 Mayis University, Samsun, Turkey.); Tumgor G ( , Trabzon, Turkey.); Kasirga E ( Tepecik Education and Research Hospital, Izmir, Turkey.); Kalayci AG ( , Trabzon, Turkey.); Aydogdu S ( Necmettin Erbakan University, Konya, Turkey.)
Abstract	BACKGROUND: This study was undertaken to evaluate demographics, clinical manifestations, laboratory findings and outcomes of children with inflammatory bowel disease (IBD) in Turkey. METHODS: We analyzed the medical records of 127 children diagnosed with IBD (under 18 years old) between January 2004 and January 2012 in 8 pediatric gastroenterology centers. RESULTS: Of the 127 patients, 90 (70.9%) suffered from ulcerative colitis (UC), 29 (22.8%) from Crohn's disease (CD), and 8 (6.3%) from IBD unclassified. The mean age of the 127 patients was 11.6 ± 4.1 years, and 11.8% of the patients were below 5 years old. Of the patients, 49.6% were male, and males were more predominant in patients with CD than in those with UC (72.4% vs. 42.2%, P = 0.008; a male/female ratio of 2.62 in CD, P = 0.0016). Approximately one fifth of the patients had extra-intestinal manifestations and 13.3% of the patients had associated diseases. Extraintestinal manifestations and associated diseases were more common in early onset disease [P = 0.017, odds ratio (OR) = 4.02; P = 0.03, OR = 4.1]. Of the patients, 15% had normal laboratory parameters including anemia, high platelet count, hypoalbuminemia, hypoferritinemia, and high sedimentation rate. Area under receiver operation characteristics was used to predict pancolitis in patients with UC. The values of C-reactive protein, sedimentation rate and pediatric ulcerative colitis activity were 0.61 (P = 0.06), 0.66 (P = 0.01) and 0.76 (P = 0.0001), respectively. Four (4.4%) patients with UC underwent colectomy, and finally two (1.5%, 95% confidence interval: 0-3.7%) patients died from primary disease or complications. CONCLUSIONS: IBD is an increasing clinical entity in Turkey. Features of IBD are similar to those in other populations, but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.
File Format	HTM / HTML
ISSN	17088569
Issue Number	4
Volume Number	11
e-ISSN	18670687
Journal	World Journal of Pediatrics
Language	English
Publisher	Springer
Publisher Date	2015-11-01
Publisher Place	Switzerland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pediatrics Inflammatory Bowel Diseases Epidemiology Adolescent Biopsy Child Child, Preschool Colonoscopy Female Humans Infant Complications Diagnosis Therapy Male Retrospective Studies Turkey Journal Article
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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