NDLI: The correlation between plasma cytokine levels in jaundice-free children with biliary atresia.

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The correlation between plasma cytokine levels in jaundice-free children with biliary atresia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jian, Zhi-Hong Wang, Li-Ching Lin, Chieh-Chung Wang, Jiaan-Der
Description	Country affiliation: China Author Affiliation: Jian ZH ( , Taiwan, China.); Wang LC ( Division of Pediatric Gastroenterology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung City, 40705, Taiwan, China.); Lin CC ( Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, 40201, Taiwan, China.); Wang JD ( , Taiwan, China.)
Abstract	BACKGROUND: T helper (Th) cell cytokines modulate inflammation and play a role in biliary atresia (BA). The aim of the study is a cross-sectional assessment of the levels of Th cytokines in the jaundice-free post Kasai procedure patients. METHODS: There were 40 jaundice-free patients with BA and 28 normal controls enrolled. Patients were divided into 3 groups, including normal liver function, impaired liver function, and portal hypertension. Plasma concentration of Th1 [interferon-Î³ (INF-Î³), interleukin (IL)-2], Th2 (IL-4, IL-10), Th3 [transforming growth factor-ß1 (TGF-ß1)], Th17 (IL-17) cytokines, and stromal cell-derived factor-1 (SDF-1 ) were investigated. RESULTS: The IFN-Î³ level was significantly higher in the BA patients with impaired liver function and portal hypertension than controls (P<0.0001 and P<0.0001, respectively). There was a significantly increase of TGF-ß1 in all BA groups compared with controls (P=0.003). The reduction of SDF-1 expression was found in BA groups (P<0.0001). IL-10 levels significantly correlated with aspartate aminotransferase to platelet ratio index (r=0.496, P=0.001). For the cytokine correlations, there were no correlations of Th1, Th2 and Th17 cytokine with the other measured cytokines, but TGF-ß1 was negatively correlated with SDF-1 levels (r=-0.327, P=0.039). CONCLUSIONS: IFN-Î³ and IL-10 are likely to be involved in the disease progression in BA. Besides, TGF-ß1 is found to be a suppression marker associated with SDF-1 levels and reduced production of TGF-ß1 may be associated with the disease progression.
File Format	HTM / HTML
ISSN	17088569
Issue Number	4
Volume Number	11
e-ISSN	18670687
Journal	World Journal of Pediatrics
Language	English
Publisher	Springer
Publisher Date	2015-11-01
Publisher Place	Switzerland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pediatrics Biliary Atresia Blood Cytokines Adolescent Surgery Child Child, Preschool Cross-sectional Studies Female Humans Infant Liver Function Tests Male Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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