NDLI: Genome-wide approaches in the study of microRNA biology.

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Genome-wide approaches in the study of microRNA biology.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wilbert, Melissa L. Yeo, Gene W.
Description	Country affiliation: United States Author Affiliation: Wilbert ML ( Department of Cellular and Molecular Medicine, Stem Cell Program, Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA.)
Abstract	MicroRNAs (miRNAs), a class of â¼21-23 nucleotide long non-coding RNAs (ncRNAs), have critical roles in diverse biological processes that encompass development, proliferation, apoptosis, stress response, and fat metabolism. miRNAs recognize their target mRNA transcripts by partial sequence complementarity and collectively have been estimated to regulate the majority of human genes. Consequently, misregulation of miRNAs or disruption of their target sites in genes has been implicated in a variety of human diseases ranging from cancer metastasis to neurological disorders. With the development and availability of genomic technologies and computational approaches, the field of miRNA biology has advanced tremendously over the last decade. Here we review the genome-wide approaches that have allowed for the discovery of new miRNAs, the characterization of their targets, and a systems-level view of their impact.
File Format	HTM / HTML
ISSN	19395094
e-ISSN	1939005X
DOI	10.1002/wsbm.128
Journal	Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Issue Number	5
Volume Number	3
Language	English
Publisher	Wiley
Publisher Date	2011-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Computational Biology Genome-wide Association Study Micrornas Physiology Algorithms Computational Biology Genomics Genetics Metabolism Proteomics Transcriptome Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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