NDLI: Roles of tRNA in cell wall biosynthesis.

Please wait, while we are loading the content...

Roles of tRNA in cell wall biosynthesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dare, Kiley Ibba, Michael
Description	Country affiliation: United States Author Affiliation: Dare K ( Department of Microbiology, Ohio State University, Columbus, OH, USA.)
Abstract	Recent research into various aspects of bacterial metabolism such as cell wall and antibiotic synthesis, degradation pathways, cellular stress, and amino acid biosynthesis has elucidated roles of aminoacyl-transfer ribonucleic acid (aa-tRNA) outside of translation. Although the two enzyme families responsible for cell wall modifications, aminoacyl-phosphatidylglycerol synthases (aaPGSs) and Fem, were discovered some time ago, they have recently become of intense interest for their roles in the antimicrobial resistance of pathogenic microorganisms. The addition of positively charged amino acids to phosphatidylglycerol (PG) by aaPGSs neutralizes the lipid bilayer making the bacteria less susceptible to positively charged antimicrobial agents. Fem transferases utilize aa-tRNA to form peptide bridges that link strands of peptidoglycan. These bridges vary among the bacterial species in which they are present and play a role in resistance to antibiotics that target the cell wall. Additionally, the formation of truncated peptides results in shorter peptide bridges and loss of branched linkages which makes bacteria more susceptible to antimicrobials. A greater understanding of the structure and substrate specificity of this diverse enzymatic family is necessary to aid current efforts in designing potential bactericidal agents. These two enzyme families are linked only by the substrate with which they modify the cell wall, aa-tRNA; their structure, cell wall modification processes and the physiological changes they impart on the bacterium differ greatly.
File Format	HTM / HTML
ISSN	17577004
e-ISSN	17577012
DOI	10.1002/wrna.1108
Journal	Wiley Interdisciplinary Reviews: RNA
Issue Number	2
Volume Number	3
Language	English
Publisher	Wiley
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology Aminoacyltransferases Metabolism Bacteria Enzymology Cell Wall Rna, Transfer Bacterial Proteins Drug Resistance, Bacterial Peptidoglycan
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Resistance to antibiotics targeted to the bacterial cell wall.

Monitoring Lys-tRNA(Lys) phosphatidylglycerol transferase activity.

Lipid II-independent trans editing of mischarged tRNAs by the penicillin resistance factor MurM.

Sortase, a universal target for therapeutic agents against gram-positive bacteria?

Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistance

Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria.

O-Acetylation of Peptidoglycan in Gram-negative Bacteria IDENTIFICATION AND CHARACTERIZATION OF PEPTIDOGLYCAN O-ACETYLTRANSFERASE IN NEISSERIA GONORRHOEAE

Cell wall anchor structure of BcpA pili in Bacillus anthracis.

Evidence for late resolution of the aux codon box in evolution.

Roles of tRNA in cell wall biosynthesis.

Similar Documents

Resistance to antibiotics targeted to the bacterial cell wall.

Monitoring Lys-tRNA(Lys) phosphatidylglycerol transferase activity.

Lipid II-independent trans editing of mischarged tRNAs by the penicillin resistance factor MurM.

Sortase, a universal target for therapeutic agents against gram-positive bacteria?

Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistance

Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria.

O-Acetylation of Peptidoglycan in Gram-negative Bacteria IDENTIFICATION AND CHARACTERIZATION OF PEPTIDOGLYCAN O-ACETYLTRANSFERASE IN NEISSERIA GONORRHOEAE

Cell wall anchor structure of BcpA pili in Bacillus anthracis.

Evidence for late resolution of the aux codon box in evolution.

Roles of tRNA in cell wall biosynthesis.