NDLI: The structures of nonprotein-coding RNAs that drive internal ribosome entry site function.

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The structures of nonprotein-coding RNAs that drive internal ribosome entry site function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Plank, Terra-Dawn M. Kieft, Jeffrey S.
Description	Country affiliation: United States Author Affiliation: Plank TD ( Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, CO, USA.)
Abstract	Internal ribosome entry sites (IRESs) are RNA sequences that can recruit the translation machinery independent of the 5' end of the messenger RNA. IRESs are found in both viral and cellular RNAs and are important for regulating gene expression. There is great diversity in the mechanisms used by IRESs to recruit the ribosome and this is reflected in a variety of RNA sequences that function as IRESs. The ability of an RNA sequence to function as an IRES is conferred by structures operating at multiple levels from primary sequence through higher-order three-dimensional structures within dynamic ribonucleoproteins (RNPs). When these diverse structures are compared, some trends are apparent, but overall it is not possible to find universal rules to describe IRES structure and mechanism. Clearly, many different sequences and structures have evolved to perform the function of recruiting, positioning, and activating a ribosome without using the canonical cap-dependent mechanism. However, as our understanding of the specific sequences, structures, and mechanisms behind IRES function improves, more common features may emerge to link these diverse RNAs.
File Format	HTM / HTML
ISSN	17577004
e-ISSN	17577012
DOI	10.1002/wrna.1105
Journal	Wiley Interdisciplinary Reviews: RNA
Issue Number	2
Volume Number	3
Language	English
Publisher	Wiley
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology Nucleic Acid Conformation Rna, Untranslated Chemistry Genetics Ribosomes Metabolism Gene Expression Regulation Models, Biological Models, Molecular Protein Biosynthesis Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry

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Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome.

IRES-induced conformational changes in the ribosome and the mechanism of translation initiation by internal ribosomal entry.

Folding of noncoding RNAs during transcription facilitated by pausing-induced nonnative structures.

Structure and function of the T-loop structural motif in noncoding RNAs.

Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection.

Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry.

The small subunit processome in ribosome biogenesisprogress and prospects.

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and function.

Computational analysis of noncoding RNAs.

The structures of nonprotein-coding RNAs that drive internal ribosome entry site function.

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Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome.

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