NDLI: Chemopreventive efficacy of geraniol against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.

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Chemopreventive efficacy of geraniol against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.

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Chemopreventive efficacy of geraniol against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vinothkumar, Veerasamy Manoharan, Shanmugam
Description	Country affiliation: India Author Affiliation: Vinothkumar V ( Department of Biochemistry & Biotechnology, Annamalai University, Tamil Nadu, India.)
Abstract	The status of lipid peroxidation, antioxidants, and detoxification enzymes were used as biochemical end points to assess the chemopreventive potential of geraniol, a monoterpene, in 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Topical application of 0.5% DMBA in liquid paraffin, three times a week, for 14 weeks developed well-differentiated squamous cell carcinoma in the buccal pouch of golden Syrian hamsters. Although 100% tumor formation was noticed in hamsters treated with DMBA alone, intragastric administration of geraniol, at a dose of 250 mg/kg body weight (b.w.) to DMBA-treated hamster completely prevented the formation of oral tumors. Furthermore, geraniol significantly reduced lipid peroxidation by-products and improved the status of enzymatic and non-enzymatic antioxidants as well as modulated the status of phase I and phase II detoxification enzymes, favoring the excretion of carcinogenic metabolite, during DMBA-induced oral carcinogenesis. The present study concludes that the chemopreventive potential of geraniol relies on its anti-lipid peroxidative and antioxidant function as well as modulatory effects on phase I and II detoxification enzymes to excrete the carcinogenic metabolite, during DMBA-induced hamster buccal pouch carcinogenesis.
File Format	HTM / HTML
ISSN	13510002
e-ISSN	17432928
Journal	Redox Report
Issue Number	3
Volume Number	16
Language	English
Publisher	Taylor & Francis
Publisher Date	2011-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Metabolism Discipline Biochemistry Carcinoma, Squamous Cell Prevention & Control Mouth Mucosa Pathology Mouth Neoplasms Terpenes Therapeutic Use 9,10-dimethyl-1,2-benzanthracene Administration & Dosage Toxicity Animals Anticarcinogenic Agents Antioxidants Metabolism Chemically Induced Drug Therapy Catalase Cricetinae Glutathione Transferase Inactivation, Metabolic Lipid Peroxidation Mesocricetus Superoxide Dismutase Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Cell Biology Physiology Biochemistry Clinical Biochemistry

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