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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hsu, Yih-Chih Yang, Deng-Fu Chiang, Chun-Pin Lee, Jeng-Woei Tseng, Meng-Kai |
| Description | Country affiliation: Taiwan Author Affiliation: Hsu YC ( Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, Taiwan. ivyhsu@cycu.edu.tw) |
| Abstract | BACKGROUND: Our previous studies found that topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (ALA-PDT) with a light dose of 100 J/cm(2) is very effective for human oral precancerous lesions. METHODS: In this study, 20 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch precancerous lesions were treated by topical ALA-PDT with a light dose of either 75 J/cm(2) (n = 10) or 100 J/cm(2) (n = 10) using a 640-nm light-emitting diode (LED) light to test which light dose could achieve a better clinical outcome. RESULTS: The 10 precancerous lesions treated by 75-J ALA-PDT showed complete response in 8 after an average of 3.4 (range, 2-6) treatments and partial response in 2. The 10 precancerous lesions treated by 100-J ALA-PDT demonstrated complete response in 7 after an average of 4.4 (range, 3-6) treatments and partial response in 3. Fisher exact test showed no significant difference in clinical outcome between these two treatment modalities (p = 1.000). One complete-response precancerous lesion in the 75-J ALA-PDT group recurred at the end of 19-week follow-up and another complete response precancerous lesion in the 100-J ALA-PDT group recurred at the end of 16-week follow-up. Both recurrence lesions were treated by the original topical ALA-PDT regimen and demonstrated complete response after 3 PDT treatments. Furthermore, the 5 partial-response precancerous lesions developed into squamous cell carcinomas after 30-week follow-up. CONCLUSION: Our findings indicate that both the 75-J and 100-J topical ALA-PDT treatment modalities are very effective for DMBA-induced hamster buccal pouch precancerous lesions and no significant difference in clinical outcome between these two treatment modalities. |
| File Format | HTM / HTML |
| ISSN | 15721000 |
| Issue Number | 4 |
| Volume Number | 9 |
| e-ISSN | 18731597 |
| Journal | Photodiagnosis and Photodynamic Therapy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Diagnostic Imaging Discipline Therapeutics Aminolevulinic Acid Pharmacology Mouth Neoplasms Drug Therapy Photochemotherapy Methods Photosensitizing Agents Precancerous Conditions 9,10-dimethyl-1,2-benzanthracene Toxicity Animals Cheek Pathology Cricetinae Male Mesocricetus Chemically Induced Spectrometry, Fluorescence Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biophysics Dermatology Pharmacology (medical) Oncology |
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