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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Messaoudi, Michaël Bisson, Jean-François Nejdi, Amine Rozan, Pascale Javelot, Hervé |
| Description | Country affiliation: France Author Affiliation: Messaoudi M ( ETAP-Applied Ethology, Centre de Recherche en Pharmacologie, Cancérologie & Pathologies Humaines et Nutrition-Santé, Vandoeuvre-lès-Nancy, France. etap@etap-lab.com) |
| Abstract | Depression is a major public health problem affecting about 12% of the world population. Drugs exist but they have many side effects. In the last few years, natural substances (e.g. flavonoids) have been tested to cure such disorders. Cocoa polyphenolic extract is a complex compound prepared from non-roasted cocoa beans containing high levels of flavonoids. The antidepressant-like effect of cocoa polyphenolic extract was evaluated using the forced swimming test in rats. Cocoa polyphenolic extract significantly reduced the duration of immobility at both doses of 24 mg/kg/14 days and 48 mg/kg/14 days, although no change of motor dysfunction was observed with the two doses tested in the open field. The results of the forced swimming test after a subchronic treatment and after an additional locomotor activity test confirm the assumption that the antidepressant-like effect of cocoa polyphenolic extract in the forced swimming test model is specific. Further, it can be speculated that this effect might be related to its content of active polyphenols. |
| File Format | HTM / HTML |
| ISSN | 1028415X |
| Issue Number | 6 |
| Volume Number | 11 |
| e-ISSN | 14768305 |
| Journal | Nutritional Neuroscience |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2008-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Discipline Nutritional Sciences Antidepressive Agents Administration & Dosage Cacao Chemistry Flavonoids Phenols Seeds Animals Body Weight Drug Effects Imipramine Immobility Response, Tonic Male Motor Activity Plant Extracts Polyphenols Rats Swimming Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Nutrition and Dietetics Medicine |
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