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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bisson, Jean-François Nejdi, Amine Rozan, Pascale Hidalgo, Sophie Lalonde, Robert Messaoudi, Michaël |
| Description | Country affiliation: France Author Affiliation: Bisson JF ( ETAP-Applied Ethology, 13 rue du Bois de la Champelle, Vandoeuvre-lès-Nancy 54500, France.) |
| Abstract | Numerous studies have indicated that increased vulnerability to oxidative stress may be the main factor involved in functional declines during normal and pathological ageing, and that antioxidant agents, such as polyphenols, may improve or prevent these deficits. We examined whether 1-year administration of a cocoa polyphenolic extract (Acticoa powder), orally delivered at the dose of 24 mg/kg per d between 15 and 27 months of age, affects the onset of age-related cognitive deficits, urinary free dopamine levels and lifespan in old Wistar-Unilever rats. Acticoa powder improved cognitive performances in light extinction and water maze paradigms, increased lifespan and preserved high urinary free dopamine levels. These results suggest that Acticoa powder may be beneficial in retarding age-related brain impairments, including cognitive deficits in normal ageing and perhaps neurodegenerative diseases. Further studies are required to elucidate the mechanisms of cocoa polyphenols in neuroprotection and to explore their effects in man. |
| File Format | HTM / HTML |
| ISSN | 00071145 |
| Issue Number | 1 |
| Volume Number | 100 |
| e-ISSN | 14752662 |
| Journal | British Journal of Nutrition |
| Language | English |
| Publisher | Cambridge University Press (on behalf of The Nutrition Society) |
| Publisher Date | 2008-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Discipline Sciences Aging Drug Effects Cacao Chemistry Cognition Flavonoids Pharmacology Phenols Psychology Animals Antioxidants Administration & Dosage Conditioning, Operant Dopamine Urine Drug Administration Schedule Longevity Male Maze Learning Memory Plant Extracts Polyphenols Rats Rats, Wistar Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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