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Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration.

Introduction to the issue regarding research regarding age related macular degeneration.

Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex.

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics.

Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration.

Animal models of age related macular degeneration.

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Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shang, Fu Taylor, Allen
Description	Country affiliation: United States Author Affiliation: Shang F ( Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Boston, MA 02111, USA. fu.shang@tufts.edu)
Abstract	The accumulation of damaged or postsynthetically modified proteins and dysregulation of inflammatory responses and angiogenesis in the retina/RPE are thought be etiologically related to formation of drusen and choroidal neovascularization (CNV), hallmarks of age-related macular degeneration (AMD). The ubiquitin-proteasome pathway (UPP) plays crucial roles in protein quality control, cell cycle control and signal transduction. Selective degradation of aberrant proteins by the UPP is essential for timely removal of potentially cytotoxic damaged or otherwise abnormal proteins. Proper function of the UPP is thought to be required for cellular function. In contrast, age--or stress induced--impairment the UPP or insufficient UPP capacity may contribute to the accumulation of abnormal proteins, cytotoxicity in the retina, and AMD. Crucial roles for the UPP in eye development, regulation of signal transduction, and antioxidant responses are also established. Insufficient UPP capacity in retina and RPE can result in dysregulation of signal transduction, abnormal inflammatory responses and CNV. There are also interactions between the UPP and lysosomal proteolytic pathways (LPPs). Means that modulate the proteolytic capacity are making their way into new generation of pharmacotherapies for delaying age-related diseases and may augment the benefits of adequate nutrition, with regard to diminishing the burden of AMD.
File Format	HTM / HTML
ISSN	00982997
e-ISSN	18729452
DOI	10.1016/j.mam.2012.04.001
Journal	Molecular Aspects of Medicine
Issue Number	4
Volume Number	33
Language	English
Publisher	Elsevier
Publisher Date	2012-08-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology Macular Degeneration Etiology Metabolism Proteasome Endopeptidase Complex Retina Signal Transduction Ubiquitin Animals Glycoproteins Nf-kappa B Neovascularization, Physiologic Genetics Oxidation-reduction Oxidative Stress Proteolysis Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Medicine Clinical Biochemistry Biochemistry Molecular Biology Molecular Medicine

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