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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Petejova, Nadezda Zahalkova, Jana Duricova, Jana Kacirova, Ivana Brozmanova, Hana Urbanek, Karel Grundmann, Milan Martinek, Arnost |
| Description | Country affiliation: Czech Republic Author Affiliation: Petejova N ( Department of Internal Medicine, Faculty of Medicine, University of Ostrava and University Hospital Ostrava, Czech Republic. jankaduricova82@gmail.com) |
| Abstract | OBJECTIVE: Current dosing recommendations for administration of gentamicin to septic patients with acute kidney injury (AKI) on continuous venovenous hemofiltration (CVVH) at a filtration rate of 45 ml/kg/h are missing. AIM: To describe gentamicin pharmacokinetics and to find an optimal dosing regimen in patients on CVVH. METHODS: Seven adult patients were included. Patients received loading dose of 240 mg followed by application of maintenance dose every 24 hours. Maintenance dose was adjusted according to gentamicin C(max)/MIC ratio and drug levels simulation using a pharmacokinetic programme. RESULTS: Median total clearance (0.59-0.79 ml/min/kg) was similar to patients with normal renal function; median volume of distribution was higher than observed in non-septic patients (about 0.5 l/kg versus 0.25 l/kg). Patients with diuresis required an increase of gentamicin dose to reach C(max)/MIC ratio. CONCLUSION: Septic patients with AKI on CVVH (45 ml/kg/h) require a loading dose of 240 mg, followed by therapeutic drug monitoring to optimize maintenance dose. |
| File Format | HTM / HTML |
| ISSN | 1120009X |
| Issue Number | 2 |
| Volume Number | 24 |
| e-ISSN | 19739478 |
| Journal | Journal of Chemotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Antineoplastic Agents Discipline Anti-Infective Agents Acute Kidney Injury Drug Therapy Anti-infective Agents Pharmacokinetics Critical Illness Therapy Gentamicins Hemofiltration Sepsis Complications Etiology Adult Aged Administration & Dosage Blood Drug Monitoring Female Humans Male Metabolic Clearance Rate Middle Aged Tissue Distribution Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pharmacology Pharmacology (medical) Oncology |
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