NDLI: Effects of combination therapy with olmesartan and azelnidipine on serum osteoprotegerin in patients with hypertension.

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Effects of combination therapy with olmesartan and azelnidipine on serum osteoprotegerin in patients with hypertension.

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Effects of combination therapy with olmesartan and azelnidipine on serum osteoprotegerin in patients with hypertension.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Uzui, Hiroyasu Morishita, Tetsuji Nakano, Akira Amaya, Naoki Fukuoka, Yoshitomo Ishida, Kentaro Arakawa, Kenichiro Lee, Jong-Dae Tada, Hiroshi
Description	Country affiliation: Japan Author Affiliation: Uzui H ( 1Department of cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.)
Abstract	BACKGROUND: Vascular calcification is a potent predictor of plaque instability and cardiac events. Osteoprotegerin (OPG), well-known vascular calcification mediator, is a signaling molecule involved in bone remodeling, which has been implicated in the regulation of vascular calcification and atherogenesis. The purpose of this study was to compare the combination treatments of olmesartan/azelnidipine and olmesartan/diuretics on serum bone-related markers in patients with essential hypertension. METHODS AND RESULTS: A total of 48 patients with hypertension treated with 20 mg olmesartan were randomized to receive combination treatment with 16 mg azelnidipine (O/A group) or diuretics (1 mg indapamide; O/D group) for 12 months. Osteoprotegerin, matrix metalloproteinase 2 (MMP-2), and high-sensitive CRP (hs-CRP) were measured after 3 and 12 months of treatment. Cardio-ankle vascular index (CAVI) was measured as the arterial stiffness using a VaSera CAVI instrument at the same time points. In both groups, the systolic and diastolic blood pressure reduction is similar. Serum OPG, MMP-2, and hs-CRP were significantly decreased at 12 months in the O/A group (P < .05), while there were no significant reductions in the O/D group. CAVI was significantly improved at 12 months in both the treatment groups. The improvement in CAVI was significantly greater in the O/A group than in the O/D group. CONCLUSION: Azelnidipine, but not indapamide, combined with olmesartan, improved arterial stiffness and were associated with significant decrease in OPG, MMP-2, and hs-CRP concentrations. These results suggest that the beneficial effects of the combination treatments of olmesartan/azelnidipine on arterial stiffness are mediated by alteration in bone-remodeling and inflammatory markers.
File Format	HTM / HTML
ISSN	10742484
Issue Number	3
Volume Number	19
e-ISSN	19404034
Journal	Journal of Cardiovascular Pharmacology and Therapeutics
Language	English
Publisher	Sage Publications
Publisher Date	2014-05-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Cardiology Discipline Vascular Diseases Discipline Pharmacology Antihypertensive Agents Therapeutic Use Azetidinecarboxylic Acid Analogs & Derivatives Dihydropyridines Hypertension Drug Therapy Imidazoles Osteoprotegerin Drug Effects Tetrazoles Aged Aged, 80 And Over Angiotensin Ii Type 1 Receptor Blockers Administration & Dosage Biological Markers Blood Pressure C-reactive Protein Metabolism Calcium Channel Blockers Diuretics Drug Therapy, Combination Female Humans Hydrochlorothiazide Male Matrix Metalloproteinase 2 Middle Aged Prospective Studies Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical) Cardiology and Cardiovascular Medicine

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