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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fogari, Roberto Zoppi, Annalisa Mugellini, Amedeo Preti, Paola Perrone, Tiziano Maffioli, Pamela Derosa, Giuseppe |
| Description | Country affiliation: Italy Author Affiliation: Fogari R ( Clinica Medica II, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy. r.fogari@unipv.it) |
| Abstract | OBJECTIVE: The objective of this study was to assess the effects of valsartan or olmesartan addition to dual therapy with amlodipine + hydrochlorothiazide (HCTZ) in the treatment of stage 2 hypertension. RESEARCH DESIGN AND METHODS: 180 patients with diastolic blood pressure (DBP) ≥ 99 and < 110 mm Hg were treated with amlodipine 5 mg + HCTZ 12.5 mg combination. After 4 weeks, 149 patients whose blood pressure (BP) was not controlled, were randomized to the combination of valsartan 160 mg + amlodipine 5 mg + HCTZ 12.5 mg or olmesartan 20 mg + amlodipine 5 mg + HCTZ 12.5 mg for 4 weeks. MAIN OUTCOME MEASURES: At the end of each period, clinical and ambulatory BP measurements were recorded. RESULTS: Both triple combinations produced greater ambulatory and clinical SBP/DBP reduction than dual therapy. However, mean reduction from baseline in the valsartan + amlodipine + HCTZ-treated patients was significantly greater than in the olmesartan + amlodipine + HCTZ-treated patients. Compared with dual therapy, the add-on effect of valsartan was significantly greater than that of olmesartan, the difference being more evident for nighttime SBP/DBP values (-3.3 (95% CI 0.44 - 3.51)/3.0 (95% CI 0.59 - 3.34) mm Hg, p < 0.01). CONCLUSIONS: The addition of valsartan to amlodipine + HCTZ produced greater BP reduction than the addition of olmesartan. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 5 |
| Volume Number | 13 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Angiotensin Ii Type 1 Receptor Blockers Administration & Dosage Antihypertensive Agents Hypertension Drug Therapy Adult Aged Amlodipine Blood Pressure Drug Effects Blood Pressure Monitoring, Ambulatory Drug Combinations Female Humans Hydrochlorothiazide Imidazoles Male Middle Aged Tetrazoles Valine Analogs & Derivatives Valsartan Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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