NDLI: Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guerriero, E. Accardo, M. Capone, F. Colonna, G. Castello, G. Costantini, S.
Description	Author Affiliation: Guerriero E ( IRCCS Istituto Nazionale Tumori. eliana8@hotmail.it.)
Abstract	Selenium is an essential trace mineral of fundamental importance to human healthy and exerts its biological function through selenoproteins. In particular, Selenoprotein M (SELM) is located in the endoplasmic reticulum and contains the common redox motif of cysteine-X-X-selenocysteine type. It attracts great attention due to its high expression in brain and its potential roles as antioxidant, neuroprotective, and cytosolic calcium regulator. Recently, our group found SELM over-expression in human hepatocellular carcinoma (HCC) cell lines. In this report some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC were immunohistochemically stained and SELM expression scoring was evaluated. Our results evidence for the first time an increase of SELM expression in HCC liver tissues, and its gradual expression raise associated with an increased malignancy grade. Therefore, we propose to use i) SELM as putative marker for HCC as well as ii) simple immunohistochemistry technique to distinguish between the different grades of malignancy.
File Format	HTM / HTML
ISSN	1121760X
e-ISSN	20388306
DOI	10.4081/ejh.2014.2433
Journal	European Journal of Histochemistry
Issue Number	4
Volume Number	58
Language	English
Publisher	PagePress
Publisher Date	2014-12-01
Publisher Place	Italy
Access Restriction	Open
Subject Keyword	Discipline Histocytochemistry Carcinoma, Hepatocellular Gene Expression Regulation, Neoplastic Liver Neoplasms Neoplasm Proteins Biosynthesis Selenoproteins Metabolism Pathology Hepatitis C Immunohistochemistry Liver Cirrhosis Clinical Trial
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Biophysics

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