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Quantification of selected antidepressants and antipsychotics in clinical samples using chromatographic methods combined with mass spectrometry: A review (2006-2015).

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Quantification of selected antidepressants and antipsychotics in clinical samples using chromatographic methods combined with mass spectrometry: A review (2006-2015).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sistik, Pavel Turjap, Miroslav Iordache, Andreea Maria Saldanha, Helena M. E. B. Lemr, Karel Bednar, Petr
Description	Country affiliation: Czech Republic Author Affiliation: Sistik P ( Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacky University Olomouc, Czech Republic.); Turjap M ( Department of Pharmacology and CEITEC, Faculty of Medicine, Masaryk University, Brno, Czech Republic.); Iordache AM ( Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacky University Olomouc, Czech Republic.); Saldanha HM ( Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacky University Olomouc, Czech Republic.); Lemr K ( Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacky University Olomouc, Czech Republic.); Bednar P ( Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacky University Olomouc, Czech Republic.)
Abstract	BACKGROUND: Psychiatric disorders contribute significantly to worldwide morbidity and mortality. In the case of depression and schizophrenia, effective drug therapy is available but 30-50% of patients do not respond sufficiently to the initial treatment regimen. Apart from the development of new molecules, it is desirable to optimize treatment outcomes with agents that are currently available. Therapeutic drug monitoring (TDM) is a suitable and widely accepted approach for improving the efficacy and safety of these drugs. METHODS: A review of the relevant literature published between 2006 and January 2015. RESULTS AND CONCLUSIONS: This review describes major advances and drawbacks in the field of chromatography coupled with single or tandem mass spectrometry (LC-MS, LC-MS/MS and GC/MS) of selected antidepressants (agomelatine, vilazodone) and antipsychotics (iloperidone, asenapine, amisulpride, aripiprazole, melperone, zotepine, ziprasidone). The high specificity in combination with high sensitivity makes these techniques an attractive complementary method to traditional procedures used in routine practice for TDM.
File Format	HTM / HTML
ISSN	12138118
Journal	Biomedical Papers
Issue Number	1
Volume Number	160
Language	English
Publisher	Vydavatelství Univerzity Palackého
Publisher Date	2016-03-01
Publisher Place	Czech Republic
Access Restriction	Open
Subject Keyword	Discipline Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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