NDLI: Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus.

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Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bartakova, Vendula Kollarova, Radana Kuricova, Katarina Sebekova, Katarina Belobradkova, Jana Kankova, Katerina
Description	Country affiliation: Czech Republic Author Affiliation: Bartakova V ( Department of Pathophysiology, Faculty of Medicine, Masaryk University, Kamenice 5/A18, 625 00 Brno, Czech Republic.); Kollarova R ( Institute of Molecular BioMedicine, Medical Faculty, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovak Republic.); Kuricova K ( Department of Pathophysiology, Faculty of Medicine, Masaryk University, Kamenice 5/A18, 625 00 Brno, Czech Republic.); Sebekova K ( Institute of Molecular BioMedicine, Medical Faculty, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovak Republic.); Belobradkova J ( Diabetes Centre of the Department of Internal Medicine - Gastroenterology, University Hospital Brno, Czech Republic.); Kankova K ( Department of Pathophysiology, Faculty of Medicine, Masaryk University, Kamenice 5/A18, 625 00 Brno, Czech Republic.)
Abstract	AIMS: The objective of the study was to measure one of the circulating Advanced Glycation End Products (AGEs) - NÎµ-(carboxymethyl)lysine (CML) - in a case-control study (n = 307) of pregnant women with gestational diabetes mellitus (GDM) and physiological pregnancies and to ascertain the factors contributing to CML levels and the potential relevance of CML for selected perinatal and postpartum outcomes. METHODS: All subjects underwent oGTT between 24th and 30th week of gestation and GDM was diagnosed according to WHO criteria. CML was determined by ELISA using commercial kit. RESULTS: Unadjusted and plasma protein adjusted CML levels were significantly higher in women with GDM compared to healthy controls (P = 0.00043 and P = 1x10(-5), respectively, Mann-Whitney). CML was significantly inversely correlated with both pre- and mid-gestational BMI, however, differences between GDM and control group remained significant even after adjustment for BMI. CML levels correlated with 1-h and 2-h post-load glycaemia during oGTT. CONCLUSION: In conclusion, we found statistically significantly higher protein- and BMI-normalised CML levels measured during 24-30th week of gestation in women with GDM compared to healthy pregnant controls. Further studies are warranted to comprehensively asses the spectrum of AGEs in GDM and their relevance to future metabolic health of mother and offspring.
File Format	HTM / HTML
ISSN	12138118
Journal	Biomedical Papers
Issue Number	1
Volume Number	160
Language	English
Publisher	Vydavatelství Univerzity Palackého
Publisher Date	2016-03-01
Publisher Place	Czech Republic
Access Restriction	Open
Subject Keyword	Discipline Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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