NDLI: Analysis of association between the MUC4 g.8227C>G polymorphism and production traits in Italian heavy pigs using a selective genotyping approach.

Please wait, while we are loading the content...

Evaluation of interferon response induced by anti-myostatin shRNA constructs in goat (Capra hircus) fetal fibroblasts by quantitative real time-polymerase chain reaction.

Polymorphisms of the myostatin gene and its relationship with reproduction traits in the Bian chicken.

Detection of polymorphism and sequence characterization of Toll-like receptor 7 gene of Indian goat revealing close relationship between ruminant species.

Polymorphisms of mitochondrial ATPase 8/6 genes and association with milk production traits in Holstein cows.

Species identification of ten common farm animals based on mitochondrial 12S rRNA gene polymorphisms.

The impact of ABCG2 on bovine mammary epithelial cell proliferation.

Year: 2012 Volume: 23 Issue: 2

Year: 2012 Volume: 23 Issue: 1

Year: 2011 Volume: 22

Year: 2010 Volume: 21

Year: 2009 Volume: 20

Year: 2008 Volume: 19

Analysis of association between the MUC4 g.8227C>G polymorphism and production traits in Italian heavy pigs using a selective genotyping approach.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fontanesi, Luca Bertolini, Francesca Dall'Olio, Stefania Buttazzoni, Luca Gallo, Maurizio Russo, Vincenzo
Spatial Coverage	Italy
Description	Country affiliation: Italy Author Affiliation: Fontanesi L ( Dept. of Agro-Food Science and Technology, Sezione di Allevamenti Zootecnici, University of Bologna, Bologna, Italy. luca.fontanesi@unibo.it)
Abstract	In pigs, susceptibility to enterotoxigenic Escherichia coli (ETEC) K88 strains (locus F4bcR) is determined by a dominant allele, with the recessive allele determining resistance. The susceptible allele also appeared to be associated with higher growth rate even with discordant results. A single nucleotide polymorphism (SNP) in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify susceptible pigs, substituting invasive villous adhesion tests. We herein analyzed this SNP in Italian local breeds and applied a selective genotyping approach in Italian Large White, Italian Landrace, and Italian Duroc comparing allele frequency distribution in groups of pigs with extreme estimated breeding values (EBV) for average daily gain (ADG) and backfat thickness (BFT) to evaluate if this marker is associated with these traits. Allele G (associated with susceptibility to ETEC) was associated with higher ADG and BFT in Italian Large White (P=6.66E-04 and P=0.012, respectively) and higher ADG in Italian Landrace (P=7.23E-12). This polymorphism was poorly informative in Italian Duroc. Antagonistic associations of the MUC4 g.8227C>G alleles on susceptibility to ETEC and growth performances evidence the complexity of applying marker assisted selection in pig breeding.
File Format	HTM / HTML
ISSN	10495398
Issue Number	3
Volume Number	23
e-ISSN	15322378
Journal	Animal Biotechnology
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Zoology Discipline Biotechnology Mucin-4 Genetics Sus Scrofa Growth & Development Animals Base Sequence Biotechnology Breeding Dna Primers Enterotoxigenic Escherichia Coli Pathogenicity Escherichia Coli Infections Microbiology Veterinary Female Gene Frequency Genotyping Techniques Italy Linkage Disequilibrium Polymorphism, Single Nucleotide Receptors, Immunologic Swine Swine Diseases Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology Bioengineering Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in