NDLI: Additional resources and the default mode network: Evidence of increased connectivity and decreased white matter integrity in amyotrophic lateral sclerosis.

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Additional resources and the default mode network: Evidence of increased connectivity and decreased white matter integrity in amyotrophic lateral sclerosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Heimrath, Johanna Gorges, Martin Kassubek, Jan Müller, Hans-Peter Birbaumer, Niels Ludolph, Albert C. Lulé, Dorothée
Description	Country affiliation: Germany Author Affiliation: Heimrath J ( Department of Neurology, University of Ulm , Ulm , Germany.)
Abstract	In amyotrophic lateral sclerosis (ALS), cognition is affected. Cortical atrophy in frontal and temporal areas has been associated with the cognitive profile of patients. Additionally, reduced metabolic turnover and regional cerebral blood flow in frontal areas indicative of reduced neural activity have been reported for ALS. We hypothesize that functional connectivity in non-task associated functional default mode network (DMN) is associated with cognitive profile and white matter integrity. This study focused on specific cognitive tasks known to be impaired in ALS such as verbal fluency and attention, and the relationship with functional connectivity in the DMN and white matter integrity. Nine patients and 11 controls were measured with an extensive neuropsychological battery. Resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data were acquired. Results showed that ALS patients performed significantly worse in attention and verbal fluency task. Patients showed increased functional connectivity in parahippocampal and parietal areas of the non-task associated DMN compared to controls. The more pronounced the cognitive deficits, the stronger the increase in functional connectivity in those areas. White matter integrity was reduced in frontal areas in the patients. In conclusion, increased connectivity in the DMN in parahippocampal and parietal areas might represent recruitment of accessory brain regions to compensate for dysfunctional frontal networks.
File Format	HTM / HTML
ISSN	21678421
Issue Number	7-8
Volume Number	15
e-ISSN	21679223
Journal	Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neurology Amyotrophic Lateral Sclerosis Complications Leukoencephalopathies Etiology Pathology Neural Pathways White Matter Adult Aged Atrophy Brain Mapping Case-control Studies Cognition Disorders Diagnosis Diffusion Magnetic Resonance Imaging Female Humans Image Processing, Computer-assisted Magnetic Resonance Imaging Male Middle Aged Blood Supply Neuropsychological Tests Oxygen Blood Rest Statistics, Nonparametric Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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