NDLI: Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis

Content Provider	Springer Nature Link
Author	Zhang, Yuanchao Fang, Tao Wang, Yue Guo, Xin Alarefi, Abdulqawi Wang, Jian Jiang, Tianzi Zhang, Jiuquan
Copyright Year	2016
Abstract	Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the present study, we applied a surface-based local gyrification index (LGI) from high resolution MRI data to quantify the cortical folding in matched samples of 25 ALS patients versus 25 healthy controls. Using resting-state fMRI data, we further conducted seed-based functional connectivity analysis to explore the functional correlate of the cortical folding changes. We found that ALS patients had significantly reduced LGI in right occipital cortex and that abnormality in this region associated with decreased functional connectivity in the bilateral precuneus. This set of findings was speculated to result from disturbed white matter connectivity in ALS. In the patient group, we revealed significant negative correlations between disease duration and the LGIs of a cluster in the left superior frontal gyrus, which may reflect the cognitive deterioration in ALS. In summary, our results suggest that LGI may provide a useful means to assess ALS-related neurodegeneration and to study the pathophysiology of ALS.
Starting Page	1
Ending Page	7
Page Count	7
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	11
Issue Number	1
e-ISSN	19317565
Language	English
Publisher	Springer US
Publisher Date	2016-01-16
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Amyotrophic lateral sclerosis Cortical folding Local gyrification index Functional connectivity White matter connectivity Neurosciences Neuroradiology Neuropsychology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

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