NDLI: Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity.

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Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity.

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Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Li-Nan Hao, Liang Wang, Hai-Yan Su, Hong-Ning Sun, Yong-Jun Yang, Xiao-Yue Che, Bin Xue, Jiao Gao, Zi Bin
Description	Country affiliation: China Author Affiliation: Zhang LN ( Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China); Hao L ( Department of Neurosurgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.); Wang HY ( Pharmaceutical Preparation Section, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.); Su HN ( Pharmaceutical Preparation Section, Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.); Sun YJ ( Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China); Yang XY ( Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.); Che B ( Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.); Xue J ( Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.); Gao ZB ( Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China)
Abstract	As the major neurotransmitter in the mammalian central nervous system (CNS), excessive extracellular glutamate (Glu) can activate the Glu receptors and neuronal calcium (Ca2+) overload, then produce neurotoxicity, which is a common pathway for neuronal injury or death, and is associated with acute and chronic neurodegenerative diseases. Therefore, it has been a therapeutic strategy to investigate neuroprotective effects against Glu-induced neurotoxicity for treating both acute and chronic forms of neurodegeneration. Resveratrol (Res), as a naturally occurring polyphenol mainly found in grapes and red wine, has shown a neuroprotective effect in a variety of experimental models for neurodegenerative diseases in vitro and in vivo. This review will focus on the neuroprotective effect of Res against Glu-induced excitotoxicity in neurodegenerative diseases by blocking different Glu receptors and Ca2+ ion channels.
File Format	HTM / HTML
ISSN	18995276
e-ISSN	24512680
Journal	Advances in Clinical and Experimental Medicine
Issue Number	1
Volume Number	24
Language	English
Publisher	Wroclaw
Publisher Date	2015-01-01
Publisher Place	Poland
Access Restriction	Open
Subject Keyword	Discipline Medicine Excitatory Amino Acid Antagonists Pharmacology Glutamic Acid Toxicity Neurodegenerative Diseases Prevention & Control Neurons Drug Effects Neuroprotective Agents Stilbenes Animals Calcium Metabolism Calcium Channels Pathology Receptors, Ampa Receptors, Kainic Acid Receptors, N-methyl-d-aspartate
Content Type	Text
Resource Type	Article
Subject	Reviews and References (medical) Internal Medicine Biochemistry, Genetics and Molecular Biology Pharmacology (medical) Genetics (clinical)

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