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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Le, Trang N. Nestler, John E. Strauss, Jerome F. Wickham, Edmond P. |
| Description | Country affiliation: United States Author Affiliation: Le TN ( Department of Pediatrics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.) |
| Abstract | Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and environmental factors that potentially contribute to the pathophysiology of type 2 diabetes mellitus (T2DM). In addition to epidemiologic studies demonstrating a consistent relationship between decreased levels of serum SHBG and incident T2DM, recent genetic studies also reveal that transmission of specific polymorphisms in the SHBG gene influence the risk of T2DM. At the molecular level, the multiple interactions between SHBG and its receptors in various target tissues suggest physiologic roles for SHBG that are more complex than the simple transport of sex hormones in serum. Taken together, these data provide support for an expanded role of SHBG in the pathophysiology of insulin resistance and T2DM. |
| File Format | HTM / HTML |
| ISSN | 10432760 |
| e-ISSN | 18793061 |
| DOI | 10.1016/j.tem.2011.09.005 |
| Journal | Trends in Endocrinology & Metabolism |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Metabolism Discipline Endocrinology Diabetes Mellitus, Type 2 Metabolism Sex Hormone-binding Globulin Physiology Animals Blood Genetics Gene Expression Regulation Insulin Resistance Polymorphism, Genetic Receptors, Cell Surface Chemistry Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology |
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