NDLI: Galectins: guardians of eutherian pregnancy at the maternal-fetal interface.

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Galectins: guardians of eutherian pregnancy at the maternal-fetal interface.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Than, Nandor Gabor Romero, Roberto Kim, Chong Jai McGowen, Michael R. Papp, Zoltan Wildman, Derek E.
Description	Country affiliation: United States Author Affiliation: Than NG ( Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Detroit, MI, USA. nthan@med.wayne.edu)
Abstract	Galectins are multifunctional regulators of fundamental cellular processes. They are also involved in innate and adaptive immune responses, and play a functional role in immune-endocrine crosstalk. Some galectins have attracted attention in the reproductive sciences because they are highly expressed at the maternal-fetal interface, their functional significance in eutherian pregnancies has been documented, and their dysregulated expression is observed in the 'great obstetrical syndromes'. The evolution of these galectins has been linked to the emergence of eutherian mammals. Based on published evidence, galectins expressed at the maternal-fetal interface may serve as important proteins involved in maternal-fetal interactions, and the study of these galectins may facilitate the prediction, prevention, diagnosis, and treatment of pregnancy complications.
File Format	HTM / HTML
ISSN	10432760
e-ISSN	18793061
DOI	10.1016/j.tem.2011.09.003
Journal	Trends in Endocrinology & Metabolism
Issue Number	1
Volume Number	23
Language	English
Publisher	Elsevier
Publisher Date	2012-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Metabolism Discipline Endocrinology Fetal Proteins Physiology Galectins Pregnancy Proteins Pregnancy Animals Chemistry Glycosylation Mammals Maternal-fetal Exchange Placentation Immunology Pregnancy Maintenance Protein Processing, Post-translational Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology

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