NDLI: Association between LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms and diabetic retinopathy of type 2 diabetes mellitus in the Chinese Han population.

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Association between LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms and diabetic retinopathy of type 2 diabetes mellitus in the Chinese Han population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lin, Xiaohui Wang, Jihong Yun, Lixia Jiang, Shuhong Li, Langen Chen, Xiaohai Li, Zhen Lu, Qiang Zhang, Yihui Ma, Xiaocheng
Description	Country affiliation: China Author Affiliation: Lin X ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China. Xiaoh_lin@163.com.); Wang J ( Department of Hand and Microsurgery II, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.); Yun L ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.); Jiang S ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.); Li L ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.); Chen X ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.); Li Z ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.); Lu Q ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.); Zhang Y ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.); Ma X ( Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.)
Abstract	BACKGROUND: Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes. The present study aimed to identify a possible connection between gene polymorphisms and the risk of developing DR. MATERIALS AND METHODS: A total of 319 patients with type 2 diabetes mellitus (T2DM) were selected. All patients underwent a complete eye examination. Based on this, the patients with T2DM were divided into two subgroups: 175 patients with retinopathy (DR) and 144 patients without retinopathy (NDR). We calculated the genotype frequencies of case and control subjects using the chi-squares test. The odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age and sex. RESULTS: The finding by analysis is that the mean of duration of diabetes, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), glomerular filtration rate and C-peptide were significantly different between DR and NDR. We found significant differences in cystatin-C concentrations with LEKR1-CCNL1 rs13064954 and NOS3 rs3918227 of different genotypes. Significant differences in serum TG levels were seen among the three genotypes of MTHFR rs1537516. Subjects carried the T allele of IGSF21-KLHDC7A rs3007729 had higher serum LDL concentrations (p = 0.015). In the allele model, LEKR1-CCNL1 rs13064954 decreased the risk of DR (OR =0.57, 95% CI = 0.34-0.96, p = 0.032). Under the dominant model, the IGSF21-KLHDC7A rs3007729 CT-TT genotype increased the risk of DR (OR =1.84, 95% CI = 1.14-2.99, p = 0.013). CONCLUSIONS: Our results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A influence the development of DR.
File Format	HTM / HTML
ISSN	1099498X
Issue Number	10
Journal	The Journal of Gene Medicine
Volume Number	18
e-ISSN	15212254
Language	English
Publisher	Wiley
Publisher Date	2016-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Drug Discovery Molecular Biology Molecular Medicine Genetics (clinical)

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