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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hua-Huy, T. Rivière, S. Tiev, K. P. Dinh-Xuan, A. T. |
| Description | Country affiliation: France Author Affiliation: Hua-Huy T ( UPRES-EA 2511, service de physiologie-explorations fonctionnelles, hôpital Cochin, AP-HP, université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.); Rivière S ( Service de médecine interne, Hôpital Saint-Antoine, université Pierre-et-Marie-Curie, 75012 Paris, France.); Tiev KP ( Hôpital privé de Vitry, site Pasteur, 94400 Vitry-sur-Seine, France.); Dinh-Xuan AT ( UPRES-EA 2511, service de physiologie-explorations fonctionnelles, hôpital Cochin, AP-HP, université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France. Electronic address: anh-tuan.dinh-xuan@cch.aphp.fr.) |
| Abstract | Interstitial lung disease (ILD) is becoming one of the main causes of death of patients with systemic sclerosis (SSc). The prevalence of ILD associated with SSc (SSc-ILD) varies from 33% to 100% according to diagnostic methods. Clinical features such as dyspnea on exertion, dry cough, and chest pains are not specific and usually late-appearing, implying more specific tests in the diagnostic, prognosis, and follow-up of ILD in patients with SSc. High resolution thoracic CT scanner (HRCT) is more sensitive than chest X-ray in the detection of SSc-ILD. Pulmonary function tests (PFT) are non-invasive and periodically used to assess the impacts of SSc on respiratory function. Diagnostic values of bronchoalveolar lavage and histological examination on lung biopsy are controversial. However, these techniques are essential for studying cellular and molecular mechanisms underlying the pathophysiology of SSc-ILD. Several biomarkers such as surfactant-A (SP-A), -D (SP-D), mucin-like high molecular weight glycoprotein (KL-6), and chemokine CCL-18 have been implicated in SSc-PID. Serum levels of these proteins are correlated with the severity of SSc-ILD, as assessed by HRCT and/or PFT. Finally, alveolar concentration of exhaled nitric oxide can be used to screen SSc patients with high risk of deterioration of respiratory function, in whom immunosuppressant treatment could be useful in preventing the evolution to irreversible lung fibrosis. |
| File Format | HTM / HTML |
| ISSN | 07618417 |
| Issue Number | 6 |
| Volume Number | 70 |
| Journal | Revue de Pneumologie Clinique |
| Language | French |
| Publisher | Elsevier |
| Publisher Date | 2014-12-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonary Medicine Biological Markers Metabolism Lung Diseases, Interstitial Diagnosis Respiratory Function Tests Methods Scleroderma, Systemic Complications Follow-up Studies Humans Etiology Sensitivity And Specificity English Abstract Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
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