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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Johannesson, M. Backman, L. Claesson, H-E Forsell, P. K. A. |
| Description | Country affiliation: Sweden Author Affiliation: Johannesson M ( Orexo AB, P.O. Box 303, 751 05 Uppsala, Stockholm, Sweden.) |
| Abstract | The enzyme 15-lipoxygenase-1 (15-LO-1) possesses mainly 15-LO activity and has so far only been described in human cells and rabbit reticulocytes. The animal ortholog, except rabbit reticulocytes, is an enzyme with predominantly a 12-lipoxygenase activity, commonly referred to as 12/15-LO. We describe herein the characterization of the 12/15-LOs in Macaca mulatta (rhesus monkey) and in Pongo pygmaeus (orang-utan). The rhesus and the orang-utan enzymes have mainly 12-lipoxygenase and 15-lipoxygenase activity, respectively, and they display 94% and 98% identity to the human 15-LO-1 protein. The rhesus enzyme was functionally different from the human enzyme with respect to substrate utilization in that anandamide was used differently and that the rhesus enzymes positional specificity could be affected by the substrate concentration. Furthermore, genomic data indicate that chimpanzees express an enzyme with mainly 15-lipoxygenase activity whereas marmosets express an enzyme with mainly 12-LO activity. Taken together, the switch during evolution from a 12-lipoxygenating enzyme in lower primates to a 15-lipoxygenating enzyme in higher primates and man might be of importance for the biological function of this enzyme. |
| File Format | HTM / HTML |
| ISSN | 09523278 |
| Issue Number | 2-3 |
| Volume Number | 82 |
| e-ISSN | 15322823 |
| Journal | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology Arachidonate 12-lipoxygenase Chemistry Metabolism Arachidonate 15-lipoxygenase Primates Amino Acid Sequence Animals Classification Genetics Arachidonic Acid Pharmacology Arachidonic Acids Cell Line Chromatography, High Pressure Liquid Cloning, Molecular Endocannabinoids Enzyme Activation Drug Effects Humans In Vitro Techniques Lung Macaca Mulatta Molecular Sequence Data Phylogeny Polymerase Chain Reaction Polyunsaturated Alkamides Pongo Pygmaeus Sequence Homology, Amino Acid Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Clinical Biochemistry |
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