NDLI: The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin.

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The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin.

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Year: 2010 Volume: 82 Issue: 4-6

Year: 2009 Volume: 81

Year: 2009 Volume: 80

The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Block, R. C. Duff, R. Lawrence, P. Kakinami, L. Brenna, J. T. Shearer, G. C. Meednu, N. Mousa, S. Friedman, A. Harris, W. S. Larson, Mark Georas, S.
Description	Country affiliation: United States Author Affiliation: Block RC ( Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Box 644, 601 Elmwood Avenue, Rochester, New York 14642, USA. robert_block@urmc.rochester.edu)
Abstract	Lysophophatidylcholine (LPC) and lysophosphatidic acid (LPA) are potent lysolipid mediators increasingly linked with atherosclerosis and inflammation. A current model proposing that plasma LPA is produced when LPC is hydrolyzed by the enzyme autotaxin has not been rigorously investigated in human subjects. We conducted a clinical trial of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) and aspirin ingestion in normal volunteers. Fasting blood samples were drawn at baseline and after 4-week supplementation with EPA/DHA (3.4 g/d) with and without aspirin (650 mg). Plasma LPC and LPA species and autotaxin activity were measured. EPA-LPC and DHA-LPC concentrations increased significantly with EPA/DHA supplementation whereas EPA- and DHA-LPA did not. Autotaxin activity was unaffected by any treatment, and aspirin had no effect on any endpoint. Taken together, our data demonstrate that plasma LPC, but not LPA, species can be dynamically regulated by dietary supplementation, and argue against a simple model of LPA generation via LPC hydrolysis.
File Format	HTM / HTML
ISSN	09523278
e-ISSN	15322823
DOI	10.1016/j.plefa.2009.12.005
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Issue Number	2-3
Volume Number	82
Language	English
Publisher	Elsevier
Publisher Date	2010-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Endocrinology Aspirin Pharmacology Docosahexaenoic Acids Eicosapentaenoic Acid Lysophospholipids Blood Multienzyme Complexes Phosphodiesterase I Pyrophosphatases Dietary Supplements Enzyme Activation Drug Effects Lipid Metabolism Lysophosphatidylcholines Models, Biological Phosphoric Diester Hydrolases Controlled Clinical Trial Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry

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The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin

The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin.