NDLI: A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study.

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A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study.

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A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yi, S. H. L. Kable, J. A. Evatt, M. L. Singh, R. H.
Description	Country affiliation: United States Author Affiliation: Yi SH ( Emory University, Nutrition & Health Sciences Program, Graduate Division of Biological & Biomedical Sciences, Atlanta, GA, USA.)
Abstract	Low blood docosahexaenoic acid (DHA) is reported in patients with phenylketonuria (PKU); however, the functional implications in adolescents and adults are unknown. This pilot study investigated the effect of supplemental DHA on cognitive performance in 33 females with PKU ages 12-47 years. Participants were randomly assigned to receive DHA (10mg/kg/day) or placebo for 4.5 months. Performance on cognitive processing speed and executive functioning tasks was evaluated at baseline and follow up. Intention-to-treat and per protocol analyses were performed. At follow up, biomarkers of DHA status were significantly higher in the DHA-supplemented group. Performance on the cognitive tasks and reported treatment-related adverse events did not differ. While no evidence of cognitive effect was seen, a larger sample size is needed to be conclusive, which may not be feasible in this population. Supplementation was a safe and effective way to increase biomarkers of DHA status (www.clinicaltrials.gov; Identifier: NCT00892554).
File Format	HTM / HTML
ISSN	09523278
e-ISSN	15322823
DOI	10.1016/j.plefa.2011.09.004
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Issue Number	6
Volume Number	85
Language	English
Publisher	Elsevier
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Endocrinology Cognition Drug Effects Dietary Supplements Docosahexaenoic Acids Therapeutic Use Nootropic Agents Phenylketonurias Drug Therapy Adolescent Adverse Effects Pharmacology Double-blind Method Erythrocytes Metabolism Fatty Acids Blood Intelligence Tests Patient Compliance Pilot Projects Randomized Controlled Trial Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry

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